Ltv1 MGI Mouse Gene Detail - MGI:2447810 - LTV1 ribosome biogenesis factor

Symbol

Ltv1
Name

LTV1 ribosome biogenesis factor
Synonyms

2610020N02Rik

Feature Type

protein coding gene
IDs

MGI:2447810
NCBI Gene: 353258
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:13054341-13068881 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 4.72 cM
Mapping Data

1 experiment

SNPs within 2kb

479 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447810	protein coding gene	Chr10:13053884-13068912 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017020	protein coding gene	Chr10:10576022-10592080 (-)
A/J	MGP_AJ_G0016998	protein coding gene	Chr10:10179343-10193839 (-)
AKR/J	MGP_AKRJ_G0016962	protein coding gene	Chr10:10405161-10419628 (-)
BALB/cJ	MGP_BALBcJ_G0016956	protein coding gene	Chr10:10177809-10192840 (-)
C3H/HeJ	MGP_C3HHeJ_G0016781	protein coding gene	Chr10:10566932-10581462 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017418	protein coding gene	Chr10:10860212-10876905 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015123	protein coding gene	Chr10:9458833-9473147 (-)
CAST/EiJ	MGP_CASTEiJ_G0016363	protein coding gene	Chr10:10429330-10443644 (-)
CBA/J	MGP_CBAJ_G0016753	protein coding gene	Chr10:11262984-11281001 (-)
DBA/2J	MGP_DBA2J_G0016861	protein coding gene	Chr10:10089186-10103480 (-)
FVB/NJ	MGP_FVBNJ_G0016856	protein coding gene	Chr10:9923801-9938921 (-)
LP/J	MGP_LPJ_G0016936	protein coding gene	Chr10:10432693-10447979 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016886	protein coding gene	Chr10:11168623-11186827 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017456	protein coding gene	Chr10:10298046-10312539 (-)
PWK/PhJ	MGP_PWKPhJ_G0016148	protein coding gene	Chr10:9970279-9984791 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015931	protein coding gene	Chr10:10438446-10452595 (-)
WSB/EiJ	MGP_WSBEiJ_G0016425	protein coding gene	Chr10:10340919-10356049 (-)

Human Ortholog

LTV1, LTV1 ribosome biogenesis factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LTV1, LTV1 ribosome biogenesis factor
Synonyms

C6orf93, dJ468K18.4, IPHAK
Links

HGNC:21173

NCBI Gene ID: 84946

neXtProt AC: NX_Q96GA3

UniProt: Q96GA3
Chr Location

6q24.2; chr6:143843338-143863812 (+) GRCh38

MGI Vertebrate Homology

Ltv1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LTV1
Gene Tree

Ltv1

Diseases

1 with human LTV1 associations

				Human Disease	Mouse Models
				inflammatory poikiloderma with hair abnormalities and acral keratoses IDs inflammatory poikiloderma with hair abnormalities and acral keratoses DOID:0070510 OMIM:620199 UMLS_CUI:C5774293

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
1 images
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Gene trapped

2
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for a knock-out allele show embryonic lethality before implantation. In vitro outgrowth assays show that morula-like embryos fail to hatch from the zona pellucida and do not form blastocysts.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

850
Tissues

31
cDNA Data

89
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ltv1

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All Sequences

35
RefSeq

4
UniProt

1
CCDS

CCDS35845.1

Ensembl

ENSMUSG00000019814 (Evidence)
NCBI Gene

353258

			Length	Strain/Species	Flank
genomic	353258	NCBI Gene Model \| MGI Sequence Detail	14541	C57BL/6J	± kb
transcript	NM_181470	RefSeq \| MGI Sequence Detail	1784	C57BL/6
polypeptide	Q6NSQ7	UniProt \| EBI \| MGI Sequence Detail	470	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009980 protein LTV1

(term hierarchy)
InterPro Domains

IPR007307 Low temperature viability protein Ltv1
GlyGen

Q6NSQ7 1 site, 1 O-linked glycan (1 site)

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All nucleic 91

cDNA 89

Primer pair 2

Microarray probesets 3

Summaries

All 30

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 7
Earliest

J:16710 Temeles GL, et al., Expression patterns of novel genes during mouse preimplantation embryogenesis. Mol Reprod Dev. 1994 Feb;37(2):121-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ltv1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96749	Chr10:13068900-13068911 (-)	-25 bp
Tssr96748	Chr10:13068840-13068899 (-)	11 bp
Tssr96747	Chr10:13068813-13068820 (-)	64 bp
Tssr96746	Chr10:13068474-13068544 (-)	372 bp
Tssr96745	Chr10:13058155-13058188 (-)	10,709 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24