Fam13b MGI Mouse Gene Detail - MGI:2447834 - family with sequence similarity 13, member B

Symbol

Fam13b
Name

family with sequence similarity 13, member B
Synonyms

2610024E20Rik

Feature Type

protein coding gene
IDs

MGI:2447834
NCBI Gene: 225358
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr18:34575404-34639884 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 18.69 cM
Mapping Data

2 experiments

SNPs within 2kb

1080 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447834	protein coding gene	Chr18:34573624-34656096 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024240	protein coding gene	Chr18:32648452-32716823 (-)
A/J	MGP_AJ_G0024206	protein coding gene	Chr18:31553922-31621090 (-)
AKR/J	MGP_AKRJ_G0024175	protein coding gene	Chr18:32448774-32517299 (-)
BALB/cJ	MGP_BALBcJ_G0024206	protein coding gene	Chr18:31615054-31679607 (-)
C3H/HeJ	MGP_C3HHeJ_G0023974	protein coding gene	Chr18:32466028-32534233 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024648	protein coding gene	Chr18:33887574-33963252 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022089	protein coding gene	Chr18:31695023-31758729 (-)
CAST/EiJ	MGP_CASTEiJ_G0023449	protein coding gene	Chr18:32405635-32476092 (-)
CBA/J	MGP_CBAJ_G0023942	protein coding gene	Chr18:34833468-34911116 (-)
DBA/2J	MGP_DBA2J_G0024074	protein coding gene	Chr18:31214167-31278612 (-)
FVB/NJ	MGP_FVBNJ_G0024040	protein coding gene	Chr18:30898263-30962487 (-)
LP/J	MGP_LPJ_G0024155	protein coding gene	Chr18:32736511-32803195 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024068	protein coding gene	Chr18:36111049-36182401 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024696	protein coding gene	Chr18:32275602-32341017 (-)
PWK/PhJ	MGP_PWKPhJ_G0023192	protein coding gene	Chr18:31398101-31463713 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023001	protein coding gene	Chr18:32536523-32606841 (-)
WSB/EiJ	MGP_WSBEiJ_G0023512	protein coding gene	Chr18:32196432-32262540 (-)

Human Ortholog

FAM13B, family with sequence similarity 13 member B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM13B, family with sequence similarity 13 member B
Synonyms

ARHGAP49, C5orf5, FAM13B1, KHCHP, N61
Links

HGNC:1335

NCBI Gene ID: 51306

neXtProt AC: NX_Q9NYF5

UniProt: Q9NYF5
Chr Location

5q31.2; chr5:137937960-138052178 (-) GRCh38

MGI Vertebrate Homology

Fam13b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM13B
Gene Tree

Fam13b

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

1
Gene trapped

11
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit normal heart size and do not develop spontaneous arrhythmia but show increased P-wave duration and QT interval and increased susceptibility to pacing-induced atrial and ventricular arrhythmias.

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

769
Tissues

37
cDNA Data

6
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam13b

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All Sequences

105
RefSeq

54
UniProt

6
CCDS

CCDS29128.1

Ensembl

ENSMUSG00000036501 (Evidence)
NCBI Gene

225358

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036501	Ensembl Gene Model \| MGI Sequence Detail	64481	C57BL/6J	± kb
transcript	ENSMUST00000040506	Ensembl \| MGI Sequence Detail	3344	Not Applicable
polypeptide	ENSMUSP00000038199	Ensembl \| MGI Sequence Detail	851	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000032024 protein FAM13B

(term hierarchy)
InterPro Domains

IPR039102 Protein FAM13

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein

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All nucleic 9

cDNA 9

Microarray probesets 2

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MGI:2147343, MGI:2147371

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fam13b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152805	Chr18:34641216-34641251 (-)	-1,350 bp
Tssr152804	Chr18:34640385-34640401 (-)	-509 bp
Tssr152803	Chr18:34639841-34639930 (-)	-2 bp
Tssr152802	Chr18:34639794-34639821 (-)	76 bp
Tssr152801	Chr18:34639717-34639737 (-)	157 bp
Tssr152800	Chr18:34624566-34624574 (-)	15,314 bp
Tssr152799	Chr18:34614451-34614497 (-)	25,410 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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