Tg(Thy1-APP)3Somm
Transgene Detail

Summary

• Symbol: Tg(Thy1-APP)3Somm
• Name: transgene insertion 3, Bernd Sommer
• MGI ID: MGI:2447146
• Synonyms: APP 23, APP23, TgAPP23, Tg(Thy1-APP)23/1Npa, Tg(Thy1APP)23Sdz, Tg(Thy1-APPK670N;M671L), Tg(Thy1-APP*Swe)3Somm
• Transgene: Tg(Thy1-APP)3Somm Location: unknown
• Alliance: Tg(Thy1-APP)3Somm page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APP)3Somm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: A mouse Thy1 promoter and a human APP751 cDNA sequence carrying the Swedish double mutation K670N and M671L found in Alzheimer's disease patients was used for the transgene. In situ hybridization analysis of brain sections from transgenic animals showed the highest levels of transgene expression in the neocortex and hippocampus. (J:44603)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

The transgene was determined to be 7-fold over-expressed.

References

• Original: J:44603 Sturchler-Pierrat C, et al., Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13287-92
• All: 199 reference(s)