H2bc8 MGI Mouse Gene Detail - MGI:2448386

Symbol

H2bc8
Name

H2B clustered histone 8
Synonyms

Hist1h2bg

Feature Type

protein coding gene
IDs

MGI:2448386
NCBI Gene: 319181
Member of

Hist1 cluster
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:23755574-23756037 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 9.80 cM, cytoband A2-A3
Mapping Data

1 experiment

SNPs within 2kb

187 from dbSNP Build 142
Strain Annotations

15

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448386	protein coding gene	Chr13:23755570-23756187 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020356	protein coding gene	Chr13:21117664-21126411 (+)
A/J	MGP_AJ_G0020250	protein coding gene	Chr13:18607504-18613066 (+)
AKR/J	MGP_AKRJ_G0020280	protein coding gene	Chr13:20863661-20864195 (+)
BALB/cJ	MGP_BALBcJ_G0020296	protein coding gene	Chr13:20601023-20602424 (+)
C3H/HeJ	MGP_C3HHeJ_G0020038	protein coding gene	Chr13:18979339-18979749 (-)
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0018323	protein coding gene	Chr13:19412741-19413263 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0020002	protein coding gene	Chr13:20336761-20338077 (-)
DBA/2J	MGP_DBA2J_G0020126	protein coding gene	Chr13:18246015-18246507 (+)
FVB/NJ	MGP_FVBNJ_G0020166	protein coding gene	Chr13:19800013-19801732 (+)
LP/J	MGP_LPJ_G0020261	protein coding gene	Chr13:21428809-21438431 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020195	protein coding gene	Chr13:22915071-22916251 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020771	protein coding gene	Chr13:20714666-20715145 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0019190	protein coding gene	Chr13:19511328-19514249 (+)
WSB/EiJ	MGP_WSBEiJ_G0019679	protein coding gene	Chr13:20851110-20852449 (+)

Human Ortholog

H2BC4, H2B clustered histone 4

Vertebrate Orthologs

12

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

H2BC4, H2B clustered histone 4
Synonyms

dJ221C16.3, H2B.1, H2BC10, H2BC6, H2BC7, H2BC8, H2BFL, H2B/l, HIST1H2BC
Links

HGNC:4757

NCBI Gene ID: 8347

neXtProt AC: NX_P62807

UniProt: P62807
Chr Location

6p22.2; chr6:26086317-26123926 (-) GRCh38

Human Ortholog

H2BC5, H2B clustered histone 5
Synonyms

dJ221C16.6, H2B.1B, H2B/a, H2B/b, H2BFA, H2BFB, H2BFG, H2BFH, H2BFK, H2BFL, H2B/g, H2B/h, H2B/k, H2B/l, HIRIP2, HIST1H2BC, HIST1H2BD, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI
Links

HGNC:4747

NCBI Gene ID: 3017

neXtProt AC: NX_P58876, NX_P62807

UniProt: P58876
Chr Location

6p22.2; chr6:26158121-26171349 (+) GRCh38

Human Ortholog

H2BC6, H2B clustered histone 6
Synonyms

dJ221C16.8, H2BC10, H2BC4, H2BC7, H2BC8, H2BFH, H2B.h, H2B/h, HIST1H2BE
Links

HGNC:4753

NCBI Gene ID: 8344

neXtProt AC: NX_P62807

UniProt: P62807
Chr Location

6p22.2; chr6:26172059-26184655 (+) GRCh38

Human Ortholog

H2BC8, H2B clustered histone 8
Synonyms

dJ221C16.8, H2B.1A, H2B/a, H2BC10, H2BC4, H2BC6, H2BC7, H2BFA, HIST1H2BG
Links

HGNC:4746

NCBI Gene ID: 8339

neXtProt AC: NX_P62807

UniProt: P62807
Chr Location

6p22.2; chr6:26216200-26216688 (-) GRCh38

MGI Vertebrate Homology

H2bc8 stringent orthology
4 human;1 mouse;7 rat;1 zebrafish
HCOP

vertebrate homology predictions: H2BC4, H2BC5, H2BC6, H2BC8
Gene Tree

H2bc8

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Radiation induced

1
Genomic Mutations

2 involving H2bc8
Find Mice (IMSR)

7 strains or lines available

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All GO Annotations

7
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

8
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

25
RefSeq

2
CCDS

CCDS26349.1

Ensembl

ENSMUSG00000058385 (Evidence)
NCBI Gene

319181

			Length	Strain/Species	Flank
genomic	319181	NCBI Gene Model \| MGI Sequence Detail	464	C57BL/6J	± kb
transcript	NM_178196	RefSeq \| MGI Sequence Detail	464	C57BL/6
polypeptide	NP_835503	RefSeq \| MGI Sequence Detail	126	C57BL/6

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All nucleic 9

Genomic 1

cDNA 8

Microarray probesets 1

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MGI:6324981

Summaries

All 26

Developmental Gene Expression 2

Gene Ontology 1

Phenotypes 8
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

TSS for H2bc8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118835	Chr13:23755556-23755566 (+)	-13 bp
Tssr118836	Chr13:23756020-23756029 (+)	451 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24