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H2bc21 Gene Detail
Summary
  • Symbol
    H2bc21
  • Name
    H2B clustered histone 21
  • Synonyms
    Hist2h2be
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448415
    NCBI Gene: 319190
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:96128435-96131054 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 41.67 cM, cytoband F1-F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448415
 protein coding gene Chr3:96128435-96131057 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027612
 protein coding gene Chr3:97027918-97030538 (+)
A/J MGP_AJ_G0027570
 protein coding gene Chr3:93982031-93984651 (+)
AKR/J MGP_AKRJ_G0027537
 protein coding gene Chr3:96187733-96190352 (+)
BALB/cJ MGP_BALBcJ_G0027582
 protein coding gene Chr3:93762509-93765129 (+)
C3H/HeJ MGP_C3HHeJ_G0027315
 protein coding gene Chr3:96471346-96473966 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028030
 protein coding gene Chr3:100589347-100591966 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025371
 protein coding gene Chr3:90307516-90310259 (+)
CAST/EiJ MGP_CASTEiJ_G0026765
 protein coding gene Chr3:95763187-95765807 (+)
CBA/J MGP_CBAJ_G0027292
 protein coding gene Chr3:104270496-104273116 (+)
DBA/2J MGP_DBA2J_G0027431
 protein coding gene Chr3:93286742-93289361 (+)
FVB/NJ MGP_FVBNJ_G0027402
 protein coding gene Chr3:91349229-91351849 (+)
LP/J MGP_LPJ_G0027539
 protein coding gene Chr3:98338046-98340666 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027429
 protein coding gene Chr3:110369859-110372479 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028084
 protein coding gene Chr3:95819542-95822162 (+)
PWK/PhJ MGP_PWKPhJ_G0026495
 protein coding gene Chr3:93172951-93175566 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026316
 protein coding gene Chr3:94122025-94124639 (+)
WSB/EiJ MGP_WSBEiJ_G0026848
 protein coding gene Chr3:96216305-96218925 (+)



Homology
more
  • Human Ortholog
    H2BC11, H2B clustered histone 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H2BC11, H2B clustered histone 11
  • Synonyms
    H2BFR, H2BJ, H2B/r, HIST1H2BJ
  • Links
    NCBI Gene ID: 8970
    neXtProt AC: NX_P06899
    UniProt: P06899

  • Chr Location
    6p22.1; chr6:27125897-27132795 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired olfactory function and an increased lifespan of mature olfactory sensory neurons associated with decreased neuron apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    3
  • cDNA Data
    27
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068854 Ensembl Gene Model | MGI Sequence Detail 2620 C57BL/6J ±  kb
    transcript ENSMUST00000090781 Ensembl | MGI Sequence Detail 2620 Not Applicable  
    polypeptide ENSMUSP00000088287 Ensembl | MGI Sequence Detail 126 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139936, MGI:2140111, MGI:6325018
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:34961 Wang ZF, et al., Characterization of the 55-kb mouse histone gene cluster on chromosome 3. Genome Res. 1996 Aug;6(8):702-14
    • Latest
      J:353445 Feierman ER, et al., Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory. Mol Cell. 2024 Aug 8;84(15):2822-2837.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory