H4c2 Gene Detail

Summary

• Symbol
  H4c2
• Name
  H4 clustered histone 2
• Synonyms
  Hist1h4b

• Feature Type
  protein coding gene
• IDs
  MGI:2448420
  NCBI Gene: 326620
• Member of
  Hist1 cluster
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr13:23940996-23941392 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 9.91 cM, cytoband A2-A3
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  120 from dbSNP Build 142
• Strain Annotations
  17

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448420	protein coding gene	Chr13:23940920-23941392 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020364	protein coding gene	Chr13:21200920-21201316 (+)
A/J	MGP_AJ_G0020313	protein coding gene	Chr13:20809575-20810565 (+)
AKR/J	MGP_AKRJ_G0020293	protein coding gene	Chr13:21063690-21064086 (+)
BALB/cJ	MGP_BALBcJ_G0020311	protein coding gene	Chr13:20804118-20804514 (+)
C3H/HeJ	MGP_C3HHeJ_G0020115	protein coding gene	Chr13:21135701-21136097 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020748	protein coding gene	Chr13:21981039-21981435 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018336	protein coding gene	Chr13:19584765-19585161 (+)
CAST/EiJ	MGP_CASTEiJ_G0019634	protein coding gene	Chr13:20818574-20818970 (+)
CBA/J	MGP_CBAJ_G0020069	protein coding gene	Chr13:22833058-22835649 (+)
DBA/2J	MGP_DBA2J_G0020195	protein coding gene	Chr13:20338247-20338643 (+)
FVB/NJ	MGP_FVBNJ_G0020179	protein coding gene	Chr13:19988821-19989217 (+)
LP/J	MGP_LPJ_G0020268	protein coding gene	Chr13:21509115-21509511 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020206	protein coding gene	Chr13:23130923-23131319 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020790	protein coding gene	Chr13:20916496-20916892 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0019203	protein coding gene	Chr13:19720622-19721042 (+)
WSB/EiJ	MGP_WSBEiJ_G0019692	protein coding gene	Chr13:21053718-21054114 (+)

Homology

• Human Ortholog
  H4C14, H4 clustered histone 14

• Vertebrate Orthologs
  16

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  H4C14, H4 clustered histone 14
  
• Synonyms
  FO108, H4, H4-16, H4C1, H4C11, H4C12, H4C13, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4F2, H4FN, H4/n, HIST2H4, HIST2H4A
• Links
  HGNC:4794

  NCBI Gene ID: 8370

  neXtProt AC: NX_P62805

  UniProt: P62805

  
  
• Chr Location
  1q21.2; chr1:149832657-149839767 (+)  GRCh38

---

• Human Ortholog
  H4C5, H4 clustered histone 5
  
• Synonyms
  H4-16, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C6, H4C8, H4C9, H4FJ, H4/j, HIST1H4E, TEBIVANED3, TEVANED3
• Links
  HGNC:4790

  NCBI Gene ID: 8367

  neXtProt AC: NX_P62805

  UniProt: P62805

  
  
• Chr Location
  6p22.2; chr6:26204610-26205021 (+)  GRCh38

---

• MGI Vertebrate Homology
  H4c2 stringent orthology
  2 human;1 mouse;4 rat;10 zebrafish
  
• HCOP
  vertebrate homology predictions: H4C14, H4C5
• Gene Tree
  H4c2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotype references
  

• All Mutations and Alleles
  3
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Radiation induced
  1
• Genomic Mutations
  2 involving H4c2
• Find Mice (IMSR)
  5 strains or lines available

Expression

• Assay Results
  737
• Tissues
  23
• cDNA Data
  2
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  29
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS26366.1

• Ensembl
  ENSMUSG00000069266 (Evidence)
• NCBI Gene
  326620

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000069266	Ensembl Gene Model | MGI Sequence Detail	397	C57BL/6J
transcript	ENSMUST00000102965	Ensembl | MGI Sequence Detail	397	Not Applicable
polypeptide	ENSMUSP00000100030	Ensembl | MGI Sequence Detail	103	Not Applicable

Protein
Information

• UniProt
  1 Sequence

Molecular
Reagents

• All nucleic 5

  Genomic 2

  cDNA 2

  Primer pair 1

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:6324964

References

• Summaries
  All 22

  Developmental Gene Expression 1

  Phenotypes 9
• Earliest
  J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
• Latest
  J:175731 Liu LJ, et al., Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development. Gene. 2011 Sep 1;483(1-2):1-10

TSS for H4c2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118864	Chr13:23940967-23940978 (+)	-23 bp