H4c4 Gene Detail

Summary

• Symbol
  H4c4
• Name
  H4 clustered histone 4
• Synonyms
  Hist1h4d

• Feature Type
  protein coding gene
• IDs
  MGI:2448423
  NCBI Gene: 319156
• Member of
  Hist1 cluster
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr13:23765551-23765952 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 9.80 cM, cytoband A2-A3
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  103 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448423	protein coding gene	Chr13:23765551-23766718 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020352	protein coding gene	Chr13:21007257-21007649 (+)
A/J	MGP_AJ_G0020305	protein coding gene	Chr13:20628795-20629500 (+)
AKR/J	MGP_AKRJ_G0020283	protein coding gene	Chr13:20873387-20873790 (+)
BALB/cJ	MGP_BALBcJ_G0020300	protein coding gene	Chr13:20625119-20625511 (+)
C3H/HeJ	MGP_C3HHeJ_G0020105	protein coding gene	Chr13:20947849-20948241 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020738	protein coding gene	Chr13:21790705-21791108 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018324	protein coding gene	Chr13:19421939-19423137 (+)
CAST/EiJ	MGP_CASTEiJ_G0019622	protein coding gene	Chr13:20635438-20635830 (+)
CBA/J	MGP_CBAJ_G0020056	protein coding gene	Chr13:22620902-22621294 (+)
DBA/2J	MGP_DBA2J_G0020183	protein coding gene	Chr13:20168148-20168540 (+)
FVB/NJ	MGP_FVBNJ_G0020168	protein coding gene	Chr13:19812707-19813295 (+)
LP/J	MGP_LPJ_G0020256	protein coding gene	Chr13:21329351-21329743 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020196	protein coding gene	Chr13:22931670-22932062 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020777	protein coding gene	Chr13:20727569-20728649 (+)
PWK/PhJ	MGP_PWKPhJ_G0019377	protein coding gene	Chr13:20194594-20195693 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019194	protein coding gene	Chr13:19527918-19533220 (+)
WSB/EiJ	MGP_WSBEiJ_G0019681	protein coding gene	Chr13:20863972-20864364 (+)

Homology

• Human Ortholog
  H4C1, H4 clustered histone 1

• Vertebrate Orthologs
  16

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  H4C1, H4 clustered histone 1
  
• Synonyms
  H4-16, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4FA, HIST1H4A
• Links
  HGNC:4781

  NCBI Gene ID: 8359

  neXtProt AC: NX_P62805

  UniProt: P62805

  
  
• Chr Location
  6p22.2; chr6:26021649-26022050 (+)  GRCh38

---

• Human Ortholog
  H4C5, H4 clustered histone 5
  
• Synonyms
  H4-16, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C6, H4C8, H4C9, H4FJ, H4/j, HIST1H4E, TEBIVANED3, TEVANED3
• Links
  HGNC:4790

  NCBI Gene ID: 8367

  neXtProt AC: NX_P62805

  UniProt: P62805

  
  
• Chr Location
  6p22.2; chr6:26204610-26205021 (+)  GRCh38

---

• MGI Vertebrate Homology
  H4c4 stringent orthology
  2 human;1 mouse;4 rat;10 zebrafish
  
• HCOP
  vertebrate homology predictions: H4C1, H4C5
• Gene Tree
  H4c4
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  2
• Chemically induced (other)
  1
• Radiation induced
  1
• Genomic Mutations
  2 involving H4c4
• Find Mice (IMSR)
  3 strains or lines available

Expression

• Assay Results
  746
• Tissues
  23
• cDNA Data
  3
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  28
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS26353.1

• Ensembl
  ENSMUSG00000061482 (Evidence)
• NCBI Gene
  319156

Representative Sequences			Length	Strain/Species
genomic	319156	NCBI Gene Model | MGI Sequence Detail	402	C57BL/6J
transcript	NM_175654	RefSeq | MGI Sequence Detail	402	C57BL/6
polypeptide	P62806	UniProt | EBI | MGI Sequence Detail	103	Not Applicable

Protein
Information

• UniProt
  1 Sequence

Molecular
Reagents

• All nucleic 5

  Genomic 1

  cDNA 3

  Primer pair 1

  
  

  Microarray probesets 1

Other
Accession IDs

MGI:6324976

References

• Summaries
  All 21

  Developmental Gene Expression 1

  Phenotypes 8
• Earliest
  J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
• Latest
  J:175731 Liu LJ, et al., Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development. Gene. 2011 Sep 1;483(1-2):1-10

TSS for H4c4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118841	Chr13:23765546-23765552 (+)	-2 bp