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Prdm13 Gene Detail
Summary
  • Symbol
    Prdm13
  • Name
    PR domain containing 13
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448528
    NCBI Gene: 230025
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:21677480-21685963 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 8.78 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448528
 protein coding gene Chr4:21675865-21685963 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028089
 protein coding gene Chr4:18693678-18702167 (-)
A/J MGP_AJ_G0028047
 protein coding gene Chr4:18136390-18144869 (-)
AKR/J MGP_AKRJ_G0028012
 protein coding gene Chr4:18544668-18553120 (-)
BALB/cJ MGP_BALBcJ_G0028058
 protein coding gene Chr4:18191788-18200269 (-)
C3H/HeJ MGP_C3HHeJ_G0027788
 protein coding gene Chr4:18725212-18733695 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028501
 protein coding gene Chr4:19455933-19464417 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025843
 protein coding gene Chr4:16794828-16803261 (-)
CAST/EiJ MGP_CASTEiJ_G0027243
 protein coding gene Chr4:18480947-18489438 (-)
CBA/J MGP_CBAJ_G0027761
 protein coding gene Chr4:20011904-20020400 (-)
DBA/2J MGP_DBA2J_G0027904
 protein coding gene Chr4:17998964-18007458 (-)
FVB/NJ MGP_FVBNJ_G0027870
 protein coding gene Chr4:17721988-17730457 (-)
LP/J MGP_LPJ_G0028013
 protein coding gene Chr4:18768329-18776784 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027903
 protein coding gene Chr4:21237349-21245832 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028560
 protein coding gene Chr4:18492725-18501200 (-)
PWK/PhJ MGP_PWKPhJ_G0026963
 protein coding gene Chr4:17830937-17839831 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026792
 protein coding gene Chr4:18318478-18326864 (-)
WSB/EiJ MGP_WSBEiJ_G0027320
 protein coding gene Chr4:18504326-18512805 (-)



Homology
more
  • Human Ortholog
    PRDM13, PR/SET domain 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDM13, PR/SET domain 13
  • Synonyms
    CDIDHH, MU-MB-20.220, PCH17, PFM10
  • Links
    NCBI Gene ID: 59336
    neXtProt AC: NX_Q9H4Q3
    UniProt: Q9H4Q3

  • Chr Location
    6q16.2; chr6:99606774-99615578 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRDM13 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a specific reduction in the number of GABAergic and glycinergic amacrine cells, a thin retinal inner nuclear layer, altered retinal inner plexiform layer morphology, and abnormally increased spatial, temporal, and contrast sensitivities in optokinetic reponses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    15
  • cDNA Data
    4
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040478 Ensembl Gene Model | MGI Sequence Detail 8484 C57BL/6J ±  kb
    transcript ENSMUST00000095141 Ensembl | MGI Sequence Detail 3173 Not Applicable  
    polypeptide ENSMUSP00000092761 Ensembl | MGI Sequence Detail 754 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 4
      Primer pair 2
      Other 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 11
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:354849 Wutikeli H, et al., Role of Elavl-like RNA-binding protein in retinal development and signal transduction. Biochim Biophys Acta Mol Basis Dis. 2024 Sep 20;1871(1):167518
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory