Pdap1 MGI Mouse Gene Detail - MGI:2448536 - PDGFA associated protein 1

Symbol

Pdap1
Name

PDGFA associated protein 1
Synonyms

HASPP28, PAP1

Feature Type

protein coding gene
IDs

MGI:2448536
NCBI Gene: 231887
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr5:145065580-145076835 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 85.04 cM
Mapping Data

2 experiments

SNPs within 2kb

334 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448536	protein coding gene	Chr5:145065579-145077048 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030357	protein coding gene	Chr5:150551971-150565165 (-)
A/J	MGP_AJ_G0030326	protein coding gene	Chr5:144085567-144096737 (-)
AKR/J	MGP_AKRJ_G0030258	protein coding gene	Chr5:148568422-148579695 (-)
BALB/cJ	MGP_BALBcJ_G0030343	protein coding gene	Chr5:145340474-145352923 (-)
C3H/HeJ	MGP_C3HHeJ_G0030054	protein coding gene	Chr5:149385372-149398709 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030788	protein coding gene	Chr5:156048382-156059852 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028009	protein coding gene	Chr5:137823035-137834677 (-)
CAST/EiJ	MGP_CASTEiJ_G0029459	protein coding gene	Chr5:148955215-148972052 (-)
CBA/J	MGP_CBAJ_G0030024	protein coding gene	Chr5:162485831-162503063 (-)
DBA/2J	MGP_DBA2J_G0030174	protein coding gene	Chr5:143801278-143812673 (-)
FVB/NJ	MGP_FVBNJ_G0030129	protein coding gene	Chr5:143036922-143049542 (-)
LP/J	MGP_LPJ_G0030263	protein coding gene	Chr5:151138146-151149751 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030160	protein coding gene	Chr5:164794943-164806241 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030828	protein coding gene	Chr5:148467428-148480755 (-)
PWK/PhJ	MGP_PWKPhJ_G0029174	protein coding gene	Chr5:142950859-142962972 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029010	protein coding gene	Chr5:146217027-146228547 (-)
WSB/EiJ	MGP_WSBEiJ_G0029534	protein coding gene	Chr5:149272697-149286869 (-)

Human Ortholog

PDAP1, PDGFA associated protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDAP1, PDGFA associated protein 1
Synonyms

HASPP28, PAP, PAP1
Links

HGNC:14634

NCBI Gene ID: 11333

neXtProt AC: NX_Q13442

UniProt: Q13442
Chr Location

7q22.1; chr7:99392048-99408597 (-) GRCh38

MGI Vertebrate Homology

Pdap1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PDAP1
Gene Tree

Pdap1

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

2
Gene trapped

17
Targeted

3
Find Mice (IMSR)

15 strains or lines available

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

17

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pdap1

ZFIN pdap1b

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All Sequences

53
RefSeq

4
UniProt

3
CCDS

CCDS39384.1

Ensembl

ENSMUSG00000029623 (Evidence)
NCBI Gene

231887

			Length	Strain/Species	Flank
genomic	231887	NCBI Gene Model \| MGI Sequence Detail	11256	C57BL/6J	± kb
transcript	NM_001033313	RefSeq \| MGI Sequence Detail	2139	C57BL/6
polypeptide	Q3UHX2	UniProt \| EBI \| MGI Sequence Detail	181	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012449 28 kDa heat- and acid-stable phosphoprotein

(term hierarchy)
InterPro Domains

IPR039876 28kDa heat- and acid-stable phosphoprotein

IPR019380 Casein kinase substrate, phosphoprotein PP28
GlyGen

Q3UHX2 1 site, 1 O-linked glycan (1 site)

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All nucleic 17

cDNA 17

Microarray probesets 6

Summaries

All 35

Gene Ontology 4

Phenotypes 11
Earliest

J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
Latest

J:298705 Delgado-Benito V, et al., PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification. J Exp Med. 2020 Oct 5;217(10)

TSS for Pdap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr54428	Chr5:145077067-145077091 (-)	-244 bp
Tssr54427	Chr5:145076821-145076856 (-)	-4 bp
Tssr54426	Chr5:145076801-145076812 (-)	28 bp
Tssr54425	Chr5:145075176-145075186 (-)	1,654 bp
Tssr54424	Chr5:145073764-145073795 (-)	3,055 bp
Tssr54423	Chr5:145073741-145073760 (-)	3,084 bp
Tssr54422	Chr5:145073204-145073221 (-)	3,622 bp
Tssr54421	Chr5:145071942-145071962 (-)	4,883 bp
Tssr54420	Chr5:145069750-145069779 (-)	7,070 bp
Tssr54419	Chr5:145069692-145069698 (-)	7,140 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24