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Fancb Gene Detail
Summary
  • Symbol
    Fancb
  • Name
    Fanconi anemia, complementation group B
  • Synonyms
    MGC:31411
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448558
    NCBI Gene: 237211
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:163763678-163780266 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 76.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    421 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448558
 protein coding gene ChrX:163763588-163780268 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036260
 protein coding gene ChrX:163097409-163114916 (+)
A/J MGP_AJ_G0036230
 protein coding gene ChrX:162233185-162249861 (+)
AKR/J MGP_AKRJ_G0036158
 protein coding gene ChrX:167469747-167486423 (+)
BALB/cJ MGP_BALBcJ_G0036223
 protein coding gene ChrX:160241752-160261388 (+)
C3H/HeJ MGP_C3HHeJ_G0035930
 protein coding gene ChrX:163421049-163437475 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036746
 protein coding gene ChrX:167865610-167883457 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033566
 protein coding gene ChrX:153252103-153268096 (+)
CAST/EiJ MGP_CASTEiJ_G0035218
 protein coding gene ChrX:142369954-142390318 (+)
CBA/J MGP_CBAJ_G0035904
 protein coding gene ChrX:172755730-172772525 (+)
DBA/2J MGP_DBA2J_G0036070
 protein coding gene ChrX:161110127-161126618 (+)
FVB/NJ MGP_FVBNJ_G0036002
 protein coding gene ChrX:160244149-160260696 (+)
LP/J MGP_LPJ_G0036155
 protein coding gene ChrX:164217479-164235288 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0036034
 protein coding gene ChrX:181436237-181454290 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036785
 protein coding gene ChrX:162579500-162598224 (+)
PWK/PhJ MGP_PWKPhJ_G0034916
 protein coding gene ChrX:139154589-139171667 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034737
 protein coding gene ChrX:142881339-142898453 (+)
WSB/EiJ MGP_WSBEiJ_G0035353
 protein coding gene ChrX:160518988-160536032 (+)



Homology
more
  • Human Ortholog
    FANCB, FA complementation group B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FANCB, FA complementation group B
  • Synonyms
    FA2, FAAP90, FAAP95, FAB, FACB
  • Links
    NCBI Gene ID: 2187
    neXtProt AC: NX_Q8NB91
    UniProt: Q8NB91

  • Chr Location
    Xp22.2; chrX:14689524-14873255 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human FANCB associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility with oligozoospermia, reduced primordial germ cells and defects in the maintenance of undifferentiated spermatogonia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 237211 NCBI Gene Model | MGI Sequence Detail 16589 C57BL/6J ±  kb
    transcript NM_001146081 RefSeq | MGI Sequence Detail 2864 C57BL/6  
    polypeptide Q5XJY6 UniProt | EBI | MGI Sequence Detail 703 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 4
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:333943 Cen C, et al., Fancb deficiency causes premature ovarian insufficiency in mice. Biol Reprod. 2022 Sep 12;107(3):790-799
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory