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Chd2 Gene Detail
Summary
  • Symbol
    Chd2
  • Name
    chromodomain helicase DNA binding protein 2
  • Synonyms
    2810013C04Rik, 2810040A01Rik, 5630401D06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448567
    NCBI Gene: 244059
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:73076400-73191494 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 41.85 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2518 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448567
 protein coding gene Chr7:73076386-73191578 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032369
 protein coding gene Chr7:74983374-75105301 (-)
A/J MGP_AJ_G0032348
 protein coding gene Chr7:73296993-73420172 (-)
AKR/J MGP_AKRJ_G0032284
 protein coding gene Chr7:74833132-74953001 (-)
BALB/cJ MGP_BALBcJ_G0032360
 protein coding gene Chr7:73053545-73170439 (-)
C3H/HeJ MGP_C3HHeJ_G0032073
 protein coding gene Chr7:75606169-75723911 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032852
 protein coding gene Chr7:78087150-78211143 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029860
 protein coding gene Chr7:75937597-76051631 (-)
CAST/EiJ MGP_CASTEiJ_G0031401
 protein coding gene Chr7:66420789-66540202 (-)
CBA/J MGP_CBAJ_G0032039
 protein coding gene Chr7:80623674-80750757 (-)
DBA/2J MGP_DBA2J_G0032194
 protein coding gene Chr7:71964140-72081057 (-)
FVB/NJ MGP_FVBNJ_G0032149
 protein coding gene Chr7:72019761-72135224 (-)
LP/J MGP_LPJ_G0032275
 protein coding gene Chr7:76208160-76332162 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032186
 protein coding gene Chr7:80768436-80887788 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032870
 protein coding gene Chr7:74305158-74427793 (-)
PWK/PhJ MGP_PWKPhJ_G0031121
 protein coding gene Chr7:65108182-65242621 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030962
 protein coding gene Chr7:61372758-61494936 (-)
WSB/EiJ MGP_WSBEiJ_G0031519
 protein coding gene Chr7:74646758-74769560 (-)



Homology
more
  • Human Ortholog
    CHD2, chromodomain helicase DNA binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHD2, chromodomain helicase DNA binding protein 2
  • Synonyms
    DEE94, EEOC
  • Links
    NCBI Gene ID: 1106
    neXtProt AC: NX_O14647
    UniProt: O14647

  • Chr Location
    15q26.1; chr15:92886203-93027996 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Chd2 mouse models; 1 with human CHD2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    84 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit early postnatal lethality associated with fetal growth retardation. Mice heterozygous for a gene trap allele exhibit postnatal lethality and premature death after weaning associated with growth retardation and multi-organ defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1004
  • Tissues
    246
  • cDNA Data
    20
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 244059 NCBI Gene Model | MGI Sequence Detail 115095 C57BL/6J ±  kb
    transcript NM_001081345 RefSeq | MGI Sequence Detail 9071 Not Specified  
    polypeptide E9PZM4 UniProt | EBI | MGI Sequence Detail 1827 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • Protein Ontology
      PR:000005408 chromodomain-helicase-DNA-binding protein 2
      (term hierarchy)
    • EC
      3.6.4.12
    • InterPro Domains
      IPR040793 CDH1/2, SANT-Helical linker 1
      IPR039880 CHD1 helical C-terminal domain containing protein 1-like
      IPR000953 Chromo/chromo shadow domain
      IPR023780 Chromo domain
      IPR023779 Chromo domain, conserved site
      IPR025260 Chromodomain-helicase-DNA-binding protein 1-like, C-terminal domain
      IPR016197 Chromo-like domain superfamily
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR009057 Homeobox-like domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR038718 SNF2-like, N-terminal domain superfamily
      IPR000330 SNF2, N-terminal
      IPR049730 SNF2/RAD5-like, C-terminal helicase domain
    • GlyGen
      E9PZM4 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 21
      Primer pair 4
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1917209, MGI:1918687, MGI:1924276, MGI:2142057
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 8
      Phenotypes 32
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory