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Carmil3 Gene Detail
Summary
  • Symbol
    Carmil3
  • Name
    capping protein regulator and myosin 1 linker 3
  • Synonyms
    Lrrc16b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448573
    NCBI Gene: 268747
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55728108-55745729 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    350 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448573
 protein coding gene Chr14:55728108-55745729 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021344
 protein coding gene Chr14:49520000-49537181 (+)
A/J MGP_AJ_G0021303
 protein coding gene Chr14:48536409-48553547 (+)
AKR/J MGP_AKRJ_G0021279
 protein coding gene Chr14:50283150-50300282 (+)
BALB/cJ MGP_BALBcJ_G0021307
 protein coding gene Chr14:48481725-48498869 (+)
C3H/HeJ MGP_C3HHeJ_G0021087
 protein coding gene Chr14:49967672-49985147 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021745
 protein coding gene Chr14:52010975-52028150 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019292
 protein coding gene Chr14:46913205-46930812 (+)
CAST/EiJ MGP_CASTEiJ_G0020606
 protein coding gene Chr14:46227698-46244842 (+)
CBA/J MGP_CBAJ_G0021054
 protein coding gene Chr14:53569880-53587058 (+)
DBA/2J MGP_DBA2J_G0021175
 protein coding gene Chr14:48256550-48273699 (+)
FVB/NJ MGP_FVBNJ_G0021157
 protein coding gene Chr14:47712024-47729136 (+)
LP/J MGP_LPJ_G0021249
 protein coding gene Chr14:50559719-50576855 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021181
 protein coding gene Chr14:52931930-52949118 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021772
 protein coding gene Chr14:49466589-49483750 (+)
PWK/PhJ MGP_PWKPhJ_G0020353
 protein coding gene Chr14:44791581-44809340 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020181
 protein coding gene Chr14:45457323-45474482 (+)
WSB/EiJ MGP_WSBEiJ_G0020659
 protein coding gene Chr14:49748072-49765543 (+)



Homology
more
  • Human Ortholog
    CARMIL3, capping protein regulator and myosin 1 linker 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CARMIL3, capping protein regulator and myosin 1 linker 3
  • Synonyms
    C14orf121, crml-1, LRRC16B
  • Links
    NCBI Gene ID: 90668
    neXtProt AC: NX_Q8ND23
    UniProt: Q8ND23

  • Chr Location
    chr14:24052009-24069729 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    868
  • Tissues
    17
  • cDNA Data
    46
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 268747 NCBI Gene Model | MGI Sequence Detail 17622 C57BL/6J ±  kb
    transcript NR_155103 RefSeq | MGI Sequence Detail 5087 C57BL/6  
    polypeptide Q3UFQ8 UniProt | EBI | MGI Sequence Detail 1375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000030677 capping protein, Arp2/3 and myosin-I linker protein 3
      (term hierarchy)
    • InterPro Domains
      IPR031943 CARMIL, C-terminal domain
      IPR041245 CARMIL, pleckstrin homology domain
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR011993 PH-like domain superfamily
      IPR051279 Protein Phosphatase 1 Regulatory and Actin Interaction Protein
    • GlyGen
      Q3UFQ8 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 46

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory