Tg(Cd4-cre)1Cwi
Transgene Detail

Summary

• Symbol: Tg(Cd4-cre)1Cwi
• Name: transgene insertion 1, Christopher B Wilson
• MGI ID: MGI:2386448
• Synonyms: CD4-Cre, CD4-Cre⁺, CD4^Cre, CD4^CRE, CD4cre, CD4-cre^Tg, CD4p-Cre, Tg(CD4-cre)^1Cw1
• Transgene: Tg(Cd4-cre)1Cwi Location: unknown Genetic Position: Chr3, Syntenic
• Alliance: Tg(Cd4-cre)1Cwi page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Cd4-cre)1Cwi expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd4 (MGI:88335)

• Mutation details: Cre recombinase is expressed under the control of mouse Cd4 regulatory elements. The Cd4 enhancer, promoter and silencer collectively drive expression at sequential stages specifically of CD4⁺ T cell development. The integration site of the transgene construct is at position 60335693-60341285 (qD) of chromosome 3 and the insert contains at least 15 complete sequential copies of the transgenic construct. (J:73127, J:302838)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd4 (mouse) Summary of all recombinase alleles driven by Cd4. Comparative matrix view of recombinase activities Alliance mouse Cd4 gene page

Disease models

Expression

In Mice Carrying this Mutation:

6 assay results 16 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 10 strains available Cell Lines: 0 lines available

References

• Original: J:73127 Lee PP, et al., A critical role for dnmt1 and DNA methylation in T cell development, function, and survival. Immunity. 2001 Nov;15(5):763-74
• All: 1634 reference(s)