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Nme7 Gene Detail
Summary
  • Symbol
    Nme7
  • Name
    NME/NM23 family member 7
  • Synonyms
    D530024H21Rik, Nm23-M7, non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase), nucleoside-diphosphate kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449121
    NCBI Gene: 171567
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:164135091-164264870 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 71.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449121
 protein coding gene Chr1:164131690-164265294 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016684
 protein coding gene Chr1:169742042-169881646 (+)
A/J MGP_AJ_G0016665
 protein coding gene Chr1:162815311-162951182 (+)
AKR/J MGP_AKRJ_G0016631
 protein coding gene Chr1:167749896-167887199 (+)
BALB/cJ MGP_BALBcJ_G0016626
 protein coding gene Chr1:163314023-163447913 (+)
C3H/HeJ MGP_C3HHeJ_G0016450
 protein coding gene Chr1:167946229-168084798 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017087
 protein coding gene Chr1:175426897-175564202 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014796
 protein coding gene Chr1:154789579-154916801 (+)
CAST/EiJ MGP_CASTEiJ_G0016030
 protein coding gene Chr1:167583349-167724360 (+)
CBA/J MGP_CBAJ_G0016425
 protein coding gene Chr1:181682451-181827252 (+)
DBA/2J MGP_DBA2J_G0016531
 protein coding gene Chr1:161703150-161833748 (+)
FVB/NJ MGP_FVBNJ_G0016529
 protein coding gene Chr1:160164609-160298434 (+)
LP/J MGP_LPJ_G0016602
 protein coding gene Chr1:170821432-170962255 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016554
 protein coding gene Chr1:189175295-189326013 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017123
 protein coding gene Chr1:167595637-167731737 (+)
PWK/PhJ MGP_PWKPhJ_G0015816
 protein coding gene Chr1:160894987-161031083 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015603
 protein coding gene Chr1:166461583-166598173 (+)
WSB/EiJ MGP_WSBEiJ_G0016092
 protein coding gene Chr1:167745855-167884113 (+)



Homology
more
  • Human Ortholog
    NME7, NME/NM23 family member 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NME7, NME/NM23 family member 7
  • Synonyms
    CFAP67, MN23H7, NDK 7, NDK7, nm23-H7
  • Links
    NCBI Gene ID: 29922
    neXtProt AC: NX_Q9Y5B8
    UniProt: Q9Y5B8

  • Chr Location
    1q24.2; chr1:169132531-169367948 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nme7 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit hydrocephaly, domed skulls and 50% exhibit situs inversus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    953
  • Tissues
    113
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 171567 NCBI Gene Model | MGI Sequence Detail 129780 C57BL/6J ±  kb
    transcript NM_178071 RefSeq | MGI Sequence Detail 2385 C57BL/6  
    polypeptide Q9QXL8 UniProt | EBI | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2441978
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 15
      Phenotypes 16
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory