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Tpm4 Gene Detail
Summary
  • Symbol
    Tpm4
  • Name
    tropomyosin 4
  • Synonyms
    2610528G24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449202
    NCBI Gene: 326618
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:72889132-72906986 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    433 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449202
 protein coding gene Chr8:72884018-72906986 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033772
 protein coding gene Chr8:72614478-72633888 (+)
A/J MGP_AJ_G0033755
 protein coding gene Chr8:69685168-69703307 (+)
AKR/J MGP_AKRJ_G0033681
 protein coding gene Chr8:71743911-71761777 (+)
BALB/cJ MGP_BALBcJ_G0033749
 protein coding gene Chr8:69812419-69830292 (+)
C3H/HeJ MGP_C3HHeJ_G0033458
 protein coding gene Chr8:72365335-72383097 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034269
 protein coding gene Chr8:75365226-75383881 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031210
 protein coding gene Chr8:64199894-64217909 (+)
CAST/EiJ MGP_CASTEiJ_G0032786
 protein coding gene Chr8:71715566-71733488 (+)
CBA/J MGP_CBAJ_G0033437
 protein coding gene Chr8:78049973-78070155 (+)
DBA/2J MGP_DBA2J_G0033591
 protein coding gene Chr8:69418224-69436175 (+)
FVB/NJ MGP_FVBNJ_G0033536
 protein coding gene Chr8:68497401-68515595 (+)
LP/J MGP_LPJ_G0033680
 protein coding gene Chr8:72710623-72728490 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033580
 protein coding gene Chr8:80560894-80579195 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034286
 protein coding gene Chr8:71762975-71780858 (+)
PWK/PhJ MGP_PWKPhJ_G0032493
 protein coding gene Chr8:68679557-68694266 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032330
 protein coding gene Chr8:70736447-70754125 (+)
WSB/EiJ MGP_WSBEiJ_G0032901
 protein coding gene Chr8:72106996-72127012 (+)



Homology
more
  • Human Ortholog
    TPM4, tropomyosin 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPM4, tropomyosin 4
  • Synonyms
    BDPLT25, HEL-S-108
  • Links
    NCBI Gene ID: 7171
    neXtProt AC: NX_P67936
    UniProt: P67936

  • Chr Location
    19p13.12-p13.11; chr19:16067021-16103002 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TPM4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Tpm4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    11 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    209
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 326618 NCBI Gene Model | MGI Sequence Detail 17855 C57BL/6J ±  kb
transcript NM_001001491 RefSeq | MGI Sequence Detail 2099 C57BL/6  
polypeptide Q6IRU2 UniProt | EBI | MGI Sequence Detail 248 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 209
    cDNA 209

    Microarray probesets 5
Other
Accession IDs
less
MGI:1919452
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:242938 Pleines I, et al., Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. J Clin Invest. 2017 Mar 01;127(3):814-829
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory