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Tomm22 Gene Detail
Summary
  • Symbol
    Tomm22
  • Name
    translocase of outer mitochondrial membrane 22
  • Synonyms
    Tom22
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450248
    NCBI Gene: 223696
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79555069-79557063 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    105 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450248
 protein coding gene Chr15:79555062-79557601 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022081
 protein coding gene Chr15:79970522-79973525 (+)
A/J MGP_AJ_G0022042
 protein coding gene Chr15:77200335-77202096 (+)
AKR/J MGP_AKRJ_G0022017
 protein coding gene Chr15:79359766-79363523 (+)
BALB/cJ MGP_BALBcJ_G0022048
 protein coding gene Chr15:77215334-77217096 (+)
C3H/HeJ MGP_C3HHeJ_G0021819
 protein coding gene Chr15:79349731-79352830 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022491
 protein coding gene Chr15:83109417-83113777 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020021
 protein coding gene Chr15:73676280-73678076 (+)
CAST/EiJ MGP_CASTEiJ_G0021340
 protein coding gene Chr15:80057930-80060050 (+)
CBA/J MGP_CBAJ_G0021784
 protein coding gene Chr15:85697960-85703665 (+)
DBA/2J MGP_DBA2J_G0021913
 protein coding gene Chr15:76687566-76689343 (+)
FVB/NJ MGP_FVBNJ_G0021891
 protein coding gene Chr15:75714079-75716805 (+)
LP/J MGP_LPJ_G0021981
 protein coding gene Chr15:80156420-80158198 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021911
 protein coding gene Chr15:90793661-90796859 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022505
 protein coding gene Chr15:79379410-79382242 (+)
PWK/PhJ MGP_PWKPhJ_G0021082
 protein coding gene Chr15:76698394-76700189 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020919
 protein coding gene Chr15:79180852-79183198 (+)
WSB/EiJ MGP_WSBEiJ_G0021392
 protein coding gene Chr15:79766999-79768927 (+)



Homology
more
  • Human Ortholog
    TOMM22, translocase of outer mitochondrial membrane 22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOMM22, translocase of outer mitochondrial membrane 22
  • Synonyms
    1C9-2, MST065, MSTP065, TOM22
  • Links
    NCBI Gene ID: 56993
    neXtProt AC: NX_Q9NS69
    UniProt: Q9NS69

  • Chr Location
    22q13.1; chr22:38681957-38685421 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    4
  • Radiation induced
    2
  • Genomic Mutations
    3 involving Tomm22
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    13 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    12
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 223696 NCBI Gene Model | MGI Sequence Detail 1995 C57BL/6J ±  kb
transcript NM_172609 RefSeq | MGI Sequence Detail 1024 C57BL/6  
polypeptide Q9CPQ3 UniProt | EBI | MGI Sequence Detail 142 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016534 mitochondrial import receptor subunit TOM22
    (term hierarchy)
  • InterPro Domains
    IPR005683 Mitochondrial import receptor subunit Tom22
  • GlyGen
    Q9CPQ3 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 55
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 7
    Phenotypes 27
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory