Tg(Tagln-cre)1Her
Transgene Detail

Summary

• Symbol: Tg(Tagln-cre)1Her
• Name: transgene insertion 1, Joachim Herz
• MGI ID: MGI:2446975
• Synonyms: SM, SM22a-Cre, Sm22alphaCre, SM22-Cre, SM22-Cre^tg, Tag1-Cre, Tgln-Cre
• Transgene: Tg(Tagln-cre)1Her Location: unknown
• Alliance: Tg(Tagln-cre)1Her page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Tagln-cre)1Her expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Tagln

• Mutation details: The transgene consists of a Tagln (transgelin) promoter and a cre gene modified to include translational consensus and nuclear localization signals. The Tagln promoter was used to drive transgene expression in smooth muscle cells. Cre recombinase mRNA expression closely patterns endogenous transgelin expression, with the highest levels detected in the aorta, intestine, and uterus. Low levels of Cre recombinase transcript are detected in all other organs. Recombination occurs in vascular smooth muscle cells of hepatic and pulmonary arteries. No recombination has been detected in non-muscle cells. (J:76460)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tagln (species not specified) Summary of all recombinase alleles driven by Tagln. Comparative matrix view of recombinase activities

Disease models

Expression

In Mice Carrying this Mutation:

34 assay results 8 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tagln-cre)1Her

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

References

• Original: J:76460 Holtwick R, et al., Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7142-7
• All: 298 reference(s)