Tg(Tek-cre)1Ywa
Transgene Detail

Summary

• Symbol: Tg(Tek-cre)1Ywa
• Name: transgene insertion 1, Masashi Yanagisawa
• MGI ID: MGI:2450311
• Synonyms: T2Cre, TekCre, Tie-2 Cre, Tie2-Cre, Tie2Cre, Tie2Cre⁺
• Transgene: Tg(Tek-cre)1Ywa Location: unknown Genetic Position: Chr5, Syntenic
• Alliance: Tg(Tek-cre)1Ywa page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Hypomorph, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Tg(Tek-cre)1Ywa involves 1 genes/genome features (Sorcs2) View all
• Tg(Tek-cre)1Ywa expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tek (MGI:98664)

• Mutation details: This transgene expresses Cre recombinase under the control of a mouse Tek promoter and enhancer. This promoter is active in endothelial cells. Insertion within intron 1 of Sorcs2 results in the 204 bp deletion (36382105 to 36382309 on mouse chromosome 5; GRCm37/mm9 genome build) leading to reduced and variable expression. (J:67365, J:71269, J:242313)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tek (mouse) Summary of all recombinase alleles driven by Tek. Comparative matrix view of recombinase activities Alliance mouse Tek gene page

Disease models

Expression

In Mice Carrying this Mutation:	282 assay results 15 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tek-cre)1Ywa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available

References

• Original: J:67365 Kisanuki YY, et al., Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol. 2001 Feb 15;230(2):230-42
• All: 780 reference(s)