Tg(NPHS2-cre)295Lbh
Transgene Detail

Summary

• Symbol: Tg(NPHS2-cre)295Lbh
• Name: transgene insertion 295, Lawrence B Holzman
• MGI ID: MGI:2450359
• Synonyms: 2.5P-Cre, NPHS2.Cre, pod-Cre, podocin-Cre, PodoCre, Tg(NPHS2-cre)1Lbh
• Transgene: Tg(NPHS2-cre)295Lbh Location: unknown
• Alliance: Tg(NPHS2-cre)295Lbh page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(NPHS2-cre)295Lbh expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  NPHS2 (7827)

  Nphs2

  (MGI:2157018)

• Mutation details: The human NPHS2 promoter, including the entire 5' untranslated region, was used to drive cre recombinase expression in podocytes. (J:81633)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	NPHS2 (human) Summary of all recombinase alleles driven by NPHS2. Comparative matrix view of recombinase activities Alliance human NPHS2 gene page

Disease models

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

Notes

24 transgenic founders were created. Phenotypic analysis was performed on founder line #295.

References

• Original: J:81633 Moeller MJ, et al., Podocyte-specific expression of cre recombinase in transgenic mice. Genesis. 2003 Jan;35(1):39-42
• All: 208 reference(s)