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Pilra Gene Detail
Summary
  • Symbol
    Pilra
  • Name
    paired immunoglobin-like type 2 receptor alpha
  • Synonyms
    FDF03
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450529
    NCBI Gene: 231805
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137820214-137834540 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.77 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    419 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450529
 protein coding gene Chr5:137820214-137834543 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0030224
 protein coding gene Chr5:137791631-137805252 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0030676
 protein coding gene Chr5:147880521-147912228 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027894
 protein coding gene Chr5:130627756-130639756 (-)
CAST/EiJ MGP_CASTEiJ_G0029350
 protein coding gene Chr5:140890215-140905825 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0030061
 protein coding gene Chr5:136304881-136381491 (-)
FVB/NJ MGP_FVBNJ_G0030016
 protein coding gene Chr5:135497693-135541131 (-)
LP/J MGP_LPJ_G0030150
 protein coding gene Chr5:143101870-143111674 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030048
 protein coding gene Chr5:156586970-156661419 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030717
 protein coding gene Chr5:140681042-140724910 (-)
PWK/PhJ MGP_PWKPhJ_G0029063
 protein coding gene Chr5:135384000-135396868 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028899
 protein coding gene Chr5:138247185-138264939 (-)
WSB/EiJ MGP_WSBEiJ_G0029423
 protein coding gene Chr5:141415877-141446771 (-)



Homology
more
  • Human Ortholog
    PILRA, paired immunoglobin like type 2 receptor alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PILRA, paired immunoglobin like type 2 receptor alpha
  • Synonyms
    FDF03
  • Links
    NCBI Gene ID: 29992
    neXtProt AC: NX_Q9UKJ1
    UniProt: Q9UKJ1

  • Chr Location
    7q22.1; chr7:100367530-100400096 (+)  GRCh38
  • Human Ortholog
    PILRB, paired immunoglobin like type 2 receptor beta
  • Synonyms
    FDFACT1, FDFACT2
  • Links
    NCBI Gene ID: 29990
    neXtProt AC: NX_Q9UKJ0
    UniProt: Q9UKJ0

  • Chr Location
    7q22.1; chr7:100352176-100367831 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased increased alanine transferase, blood urea nitrogen, lactate dehydrogenase, neutrophils and mortality and altered liver morphology (massive hemorrhage, disorganized hepatic cords and karyolysis of hepatocytes) following treatment with LPS.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231805 NCBI Gene Model | MGI Sequence Detail 14327 C57BL/6J ±  kb
    transcript NM_153510 RefSeq | MGI Sequence Detail 2588 C57BL/6  
    polypeptide Q2YFS3 UniProt | EBI | MGI Sequence Detail 302 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR051694 Immunoregulatory Receptor-like
    • GlyGen
      Q2YFS3 2 sites
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141104
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:77738 Fournier N, et al., FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. J Immunol. 2000 Aug 1;165(3):1197-209
    • Latest
      J:342796 Zheng L, et al., The CD8alpha-PILRalpha interaction maintains CD8(+) T cell quiescence. Science. 2022 May 27;376(6596):996-1001
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory