Tg(Cyp19)C2-3Rrte
Transgene Detail

Summary

• Symbol: Tg(Cyp19)C2-3Rrte
• Name: transgene insertion C2-3, Rajeshwar Rao Tekmal
• MGI ID: MGI:2385806
• Synonyms: int-5-aromatase, MMTV-int-5-aromatase transgene
• Transgene: Tg(Cyp19)C2-3Rrte Location: unknown
• Alliance: Tg(Cyp19)C2-3Rrte page

Transgene origin

• Strain of Origin: (C57BL/6 x BALB/c)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cyp19)C2-3Rrte expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cyp19a1 (MGI:88587)

• Mutation details: This transgene was produced using a vector that contained the 2.4kb full-length mouse Cyp 19 cDNA in addition to a coding region that included -45 to -1 of 5' and a complete (860bp) 3' untranslated region under the control of a mouse mammary tumor virus promoter (MMTV). Multiple lines were generated, ranging in copy number from 1 to 30, estimated by Southern blot. This allele is representative of the high copy number variants and carries an estimated 20 copies of the gene in mammary gland tissue. (J:34063)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Cyp19)C2-3Rrte

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:34063 Tekmal RR, et al., Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities. Cancer Res. 1996 Jul 15;56(14):3180-5
• All: 12 reference(s)