Adgrb2 MGI Mouse Gene Detail - MGI:2451244 - adhesion G protein-coupled receptor B2

Symbol

Adgrb2
Name

adhesion G protein-coupled receptor B2
Synonyms

Bai2

Feature Type

protein coding gene
IDs

MGI:2451244
NCBI Gene: 230775
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:129878663-129916426 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 63.43 cM
Mapping Data

1 experiment

SNPs within 2kb

300 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2451244	protein coding gene	Chr4:129878566-129916426 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028841	protein coding gene	Chr4:131963234-132003813 (+)
A/J	MGP_AJ_G0028800	protein coding gene	Chr4:126672530-126711035 (+)
AKR/J	MGP_AKRJ_G0028753	protein coding gene	Chr4:130217004-130259446 (+)
BALB/cJ	MGP_BALBcJ_G0028823	protein coding gene	Chr4:127282066-127321132 (+)
C3H/HeJ	MGP_C3HHeJ_G0028537	protein coding gene	Chr4:130276494-130314843 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029265	protein coding gene	Chr4:136910490-136957506 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026537	protein coding gene	Chr4:119797800-119835340 (+)
CAST/EiJ	MGP_CASTEiJ_G0027969	protein coding gene	Chr4:128470362-128513025 (+)
CBA/J	MGP_CBAJ_G0028503	protein coding gene	Chr4:140383959-140427333 (+)
DBA/2J	MGP_DBA2J_G0028652	protein coding gene	Chr4:127107495-127145045 (+)
FVB/NJ	MGP_FVBNJ_G0028619	protein coding gene	Chr4:125890600-125931269 (+)
LP/J	MGP_LPJ_G0028753	protein coding gene	Chr4:132287053-132326776 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028645	protein coding gene	Chr4:145100874-145140982 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029303	protein coding gene	Chr4:130584863-130625159 (+)
PWK/PhJ	MGP_PWKPhJ_G0027691	protein coding gene	Chr4:123719561-123758220 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027517	protein coding gene	Chr4:126465625-126507936 (+)
WSB/EiJ	MGP_WSBEiJ_G0028050	protein coding gene	Chr4:130726207-130767869 (+)

Human Ortholog

ADGRB2, adhesion G protein-coupled receptor B2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADGRB2, adhesion G protein-coupled receptor B2
Synonyms

BAI2
Links

HGNC:944

NCBI Gene ID: 576

neXtProt AC: NX_O60241

UniProt: O60241
Chr Location

1p35.2; chr1:31727117-31764893 (-) GRCh38

MGI Vertebrate Homology

Adgrb2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADGRB2
Gene Tree

Adgrb2

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Phenotype Summary

4 phenotypes from 3 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Targeted

6
Genomic Mutations

4 involving Adgrb2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

71 strains or lines available

Mice homozygous for disruptions in this gene show a lessening of depression like behavior.

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All GO Annotations

20
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

871
Tissues

101
cDNA Data

57
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adgrb2

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All Sequences

93
RefSeq

34
UniProt

7
CCDS

CCDS51309.1, CCDS57300.1, CCDS71478.1, CCDS80164.1

Ensembl

ENSMUSG00000028782 (Evidence)
NCBI Gene

230775

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028782	Ensembl Gene Model \| MGI Sequence Detail	37764	C57BL/6J	± kb
transcript	ENSMUST00000030571	Ensembl \| MGI Sequence Detail	4734	Not Applicable
polypeptide	ENSMUSP00000030571	Ensembl \| MGI Sequence Detail	1577	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000004630 adhesion G protein-coupled receptor B2

(term hierarchy)
InterPro Domains

IPR043838 Adhesion G protein-coupled receptor B, N-terminal domain

IPR051867 Angiogenesis Inhibitor and Adhesion GPCR

IPR032471 GAIN domain, N-terminal

IPR046338 GAIN domain superfamily

IPR008077 GPCR, family 2, brain-specific angiogenesis inhibitor

IPR001879 GPCR, family 2, extracellular hormone receptor domain

IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily

IPR017981 GPCR, family 2-like, 7TM

IPR000832 GPCR, family 2, secretin-like

IPR000203 GPS motif

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
GlyGen

Q8CGM1 9 sites, 13 N-linked glycans (5 sites)

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All nucleic 59

cDNA 57

Primer pair 2

Microarray probesets 3

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 17
Earliest

J:77162 Kee HJ, et al., Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. J Cereb Blood Flow Metab. 2002 Sep;22(9):1054-67
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Adgrb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39211	Chr4:129878576-129878581 (+)	-84 bp
Tssr39212	Chr4:129878602-129878614 (+)	-55 bp
Tssr39213	Chr4:129878626-129878669 (+)	-15 bp
Tssr39214	Chr4:129878686-129878689 (+)	25 bp
Tssr39215	Chr4:129878891-129878947 (+)	256 bp
Tssr39216	Chr4:129900528-129900547 (+)	21,875 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24