Tlyr1 QTL Detail

Summary

• Symbol
  Tlyr1
• Name
  thymic lymphoma resistance 1

• Feature Type
  QTL
• IDs
  MGI:2651474
  NCBI Gene: 493020
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Chr19:20539528-25313796 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, 21.34 cM (cM position of peak correlated region/marker)
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Incidental Mutations
  APF
• Find Mice (IMSR)
  1 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  493020

References

• Summaries
  All 5

  Phenotypes 1
• Earliest
  J:79055 Santos J, et al., A new locus for resistance to gamma-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice. Oncogene. 2002 Sep 26;21(43):6680-3
• Latest
  J:168370 Santos J, et al., The stromal gene encoding the CD274 antigen as a genetic modifier controlling survival of mice with gamma-radiation-induced T-cell lymphoblastic lymphomas. Oncogene. 2010 Sep 23;29(38):5265-73

Candidate Genes for Tlyr1:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Cd274	Chr19:29344855-29365495 (+)	J:168370	Three overlapping segments of the Tlyr1 locus resided in three SEG/Pas subcongenic strains. One of these regions proved informative to suggest that Cd274 may be a candidate for the Tlyr1 locus.