Tub MGI Mouse Gene Detail - MGI:2651573 - TUB bipartite transcription factor

Symbol

Tub
Name

TUB bipartite transcription factor
Synonyms

rd5, tub

Feature Type

protein coding gene
IDs

MGI:2651573
NCBI Gene: 22141
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:108610087-108633666 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 57.21 cM
Mapping Data

17 experiments

SNPs within 2kb

709 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2651573	protein coding gene	Chr7:108549545-108633667 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032837	protein coding gene	Chr7:112414726-112433661 (+)
A/J	MGP_AJ_G0032821	protein coding gene	Chr7:109650845-109669768 (+)
AKR/J	MGP_AKRJ_G0032752	protein coding gene	Chr7:112383356-112402344 (+)
BALB/cJ	MGP_BALBcJ_G0032825	protein coding gene	Chr7:109347176-109367412 (+)
C3H/HeJ	MGP_C3HHeJ_G0032535	protein coding gene	Chr7:112420773-112446265 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033331	protein coding gene	Chr7:117113478-117132545 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030304	protein coding gene	Chr7:111239826-111258481 (+)
CAST/EiJ	MGP_CASTEiJ_G0031863	protein coding gene	Chr7:103947823-103988293 (+)
CBA/J	MGP_CBAJ_G0032508	protein coding gene	Chr7:120934425-120953794 (+)
DBA/2J	MGP_DBA2J_G0032660	protein coding gene	Chr7:107758658-107778017 (+)
FVB/NJ	MGP_FVBNJ_G0032613	protein coding gene	Chr7:107605215-107624142 (+)
LP/J	MGP_LPJ_G0032754	protein coding gene	Chr7:113973362-113992313 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032645	protein coding gene	Chr7:122607499-122626369 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033352	protein coding gene	Chr7:111407248-111428484 (+)
PWK/PhJ	MGP_PWKPhJ_G0031570	protein coding gene	Chr7:100561978-100600974 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031418	protein coding gene	Chr7:98031580-98130222 (+)
WSB/EiJ	MGP_WSBEiJ_G0031976	protein coding gene	Chr7:112241511-112261818 (+)

Human Ortholog

TUB, TUB bipartite transcription factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TUB, TUB bipartite transcription factor
Synonyms

rd5, RDOB
Links

HGNC:12406

NCBI Gene ID: 7275

neXtProt AC: NX_P50607

UniProt: P50607
Chr Location

11p15.4; chr11:8019059-8106243 (+) GRCh38

MGI Vertebrate Homology

Tub stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TUB
Gene Tree

Tub

Diseases

1 with Tub mouse models

Human Disease

Mouse Models

obesity

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

43 phenotypes from 3 alleles in 7 genetic backgrounds
8 phenotypes from multigenic genotypes
5 images
61 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Spontaneous

1
Targeted

4
Genomic Mutations

2 involving Tub
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants exhibit a late-developing obesity with hyperinsulinemia, retinal degeneration, and hearing loss associated with death of both outer and inner hair cells.

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All GO Annotations

27
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

902
Tissues

146
cDNA Data

13
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tub

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All Sequences

48
RefSeq

2
UniProt

6
CCDS

CCDS21732.1

Ensembl

ENSMUSG00000031028 (Evidence)
NCBI Gene

22141

			Length	Strain/Species	Flank
genomic	22141	NCBI Gene Model \| MGI Sequence Detail	23580	C57BL/6J	± kb
transcript	NM_021885	RefSeq \| MGI Sequence Detail	5941	C57BL/6
polypeptide	P50586	UniProt \| EBI \| MGI Sequence Detail	505	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000016806 tubby protein

(term hierarchy)
PDB

1C8Z, 1I7E
InterPro Domains

IPR000007 Tubby, C-terminal

IPR018066 Tubby, C-terminal, conserved site

IPR025659 Tubby-like, C-terminal

IPR005398 Tubby, N-terminal

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All nucleic 31

Genomic 8

cDNA 13

Primer pair 2

Other 8

Microarray probesets 5

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MGD-MRK-13815, MGD-MRK-15299, MGI:97886, MGI:98868

Summaries

All 106

Developmental Gene Expression 3

Diseases 2

Gene Ontology 15

Phenotypes 61
Earliest

J:10872 Coleman DL, et al., Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. J Hered. 1990 Nov-Dec;81(6):424-7
Latest

J:332791 de Oliveira Micheletti T, et al., Acute exercise reduces feeding by activating IL-6/Tubby axis in the mouse hypothalamus. Front Physiol. 2022;13:956116

TSS for Tub:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2363	Chr7:108610034-108610042 (+)	-49 bp
Tssr68464	Chr7:108610049-108610052 (+)	-36 bp
Tssr68465	Chr7:108610057-108610137 (+)	10 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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