Lcorl MGI Mouse Gene Detail - MGI:2651932 - ligand dependent nuclear receptor corepressor-like

Symbol

Lcorl
Name

ligand dependent nuclear receptor corepressor-like
Synonyms

A830039H10Rik, Mlr1

Feature Type

protein coding gene
IDs

MGI:2651932
NCBI Gene: 209707
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:45854523-46014957 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 25.31 cM
Mapping Data

2 experiments

SNPs within 2kb

2867 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2651932	protein coding gene	Chr5:45854523-46015213 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029537	protein coding gene	Chr5:44410975-44573419 (-)
A/J	MGP_AJ_G0029505	protein coding gene	Chr5:42874347-43064293 (-)
AKR/J	MGP_AKRJ_G0029453	protein coding gene	Chr5:44351594-44511528 (-)
BALB/cJ	MGP_BALBcJ_G0029514	protein coding gene	Chr5:43343817-43514713 (-)
C3H/HeJ	MGP_C3HHeJ_G0029237	protein coding gene	Chr5:44369839-44528440 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029968	protein coding gene	Chr5:46498411-46660496 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027207	protein coding gene	Chr5:40025520-40167226 (-)
CAST/EiJ	MGP_CASTEiJ_G0028645	protein coding gene	Chr5:43515587-43672580 (-)
CBA/J	MGP_CBAJ_G0029206	protein coding gene	Chr5:47784501-47955748 (-)
DBA/2J	MGP_DBA2J_G0029352	protein coding gene	Chr5:42940219-43098663 (-)
FVB/NJ	MGP_FVBNJ_G0029312	protein coding gene	Chr5:42369561-42524726 (-)
LP/J	MGP_LPJ_G0029437	protein coding gene	Chr5:44903092-45061873 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029340	protein coding gene	Chr5:48527468-48727960 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030001	protein coding gene	Chr5:43883711-44034654 (-)
PWK/PhJ	MGP_PWKPhJ_G0028369	protein coding gene	Chr5:42069769-42230350 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028203	protein coding gene	Chr5:43337390-43486274 (-)
WSB/EiJ	MGP_WSBEiJ_G0028726	protein coding gene	Chr5:43941268-44100409 (-)

Human Ortholog

LCORL, ligand dependent nuclear receptor corepressor like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LCORL, ligand dependent nuclear receptor corepressor like
Synonyms

MLR1
Links

HGNC:30776

NCBI Gene ID: 254251

neXtProt AC: NX_Q8N3X6

UniProt: Q8N3X6
Chr Location

4p15.31; chr4:17841187-18021876 (-) GRCh38

MGI Vertebrate Homology

Lcorl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LCORL
Gene Tree

Lcorl

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References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

4
Radiation induced

2
Spontaneous

1
Genomic Mutations

5 involving Lcorl
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

825
Tissues

115
cDNA Data

65
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lcorl

ZFIN lcorl

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All Sequences

68
UniProt

8
CCDS

CCDS19277.1, CCDS19278.1, CCDS51499.1, CCDS89917.1

Ensembl

ENSMUSG00000015882 (Evidence)
NCBI Gene

209707

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015882	Ensembl Gene Model \| MGI Sequence Detail	160435	C57BL/6J	± kb
transcript	ENSMUST00000238522	Ensembl \| MGI Sequence Detail	10477	Not Applicable
polypeptide	ENSMUSP00000158672	Ensembl \| MGI Sequence Detail	1851	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000009731 ligand-dependent nuclear receptor corepressor-like protein

(term hierarchy)
InterPro Domains

IPR007889 DNA binding HTH domain, Psq-type

IPR009057 Homeobox-like domain superfamily

IPR028104 Protein of unknown function DUF4553

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All nucleic 70

cDNA 69

Primer pair 1

Microarray probesets 7

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MGI:2441834, MGI:3781592

Summaries

All 54

Developmental Gene Expression 5

Diseases 1

Gene Ontology 5

Phenotypes 24
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lcorl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr50916	Chr5:46014815-46014853 (-)	123 bp
Tssr50915	Chr5:46013838-46013849 (-)	1,113 bp
Tssr50914	Chr5:45989486-45989503 (-)	25,462 bp
Tssr50913	Chr5:45980770-45980774 (-)	34,185 bp
Tssr50912	Chr5:45964021-45964025 (-)	50,934 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24