Tg(Thy1-SNCA*A30P)18Pjk
Transgene Detail

Summary

• Symbol: Tg(Thy1-SNCA*A30P)18Pjk
• Name: transgene insertion 18, Philipp J Kahle
• MGI ID: MGI:2445720
• Synonyms: [A30P]alphaSYN, Tg(Thy1-SNCA-A30P)18Pjk, Tg(Thy1-SNCA-A30P)1Pjk, (Thy1)-h[A30P]alphaS, Thy-A30P18, ThyA30P18
• Transgene: Tg(Thy1-SNCA*A30P)18Pjk Location: unknown
• Alliance: Tg(Thy1-SNCA*A30P)18Pjk page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-SNCA*A30P)18Pjk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The transgene is composed of a mouse Thy1 promoter, a human alpha synuclein (SNCA) cDNA encoding an alanine to proline substitution at amino acid 30 (A30P), and exon 4 of mouse Thy1, which contains polyadenylation signals. The A30P mutation is found in human patients with severe early onset Parkinson disease. Transgene expression is detected in the spinal cord and most areas of the brain except the substantia nigra. (J:64205)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic lines 18 and 31 expressed higher levels of the transgene than lines 8, 9, and 14.

References

• Original: J:64205 Kahle PJ, et al., Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. J Neurosci. 2000 Sep 1;20(17):6365-73
• All: 35 reference(s)