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Vgll4 Gene Detail
Summary
  • Symbol
    Vgll4
  • Name
    vestigial like family member 4
  • Synonyms
    MGC:54805, VGL-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652840
    NCBI Gene: 232334
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:114837589-114946955 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2559 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652840
 protein coding gene Chr6:114836850-114946955 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031143
 protein coding gene Chr6:117452206-117564011 (-)
A/J MGP_AJ_G0031112
 protein coding gene Chr6:112945400-113056352 (-)
AKR/J MGP_AKRJ_G0031043
 protein coding gene Chr6:115981240-116092461 (-)
BALB/cJ MGP_BALBcJ_G0031123
 protein coding gene Chr6:112760566-112870321 (-)
C3H/HeJ MGP_C3HHeJ_G0030585
 protein coding gene Chr6:68208463-68321253 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031582
 protein coding gene Chr6:120436018-120550664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028746
 protein coding gene Chr6:109967624-110074176 (-)
CAST/EiJ MGP_CASTEiJ_G0030230
 protein coding gene Chr6:116319337-116438095 (-)
CBA/J MGP_CBAJ_G0030809
 protein coding gene Chr6:125214604-125321753 (-)
DBA/2J MGP_DBA2J_G0030962
 protein coding gene Chr6:111879327-111988391 (-)
FVB/NJ MGP_FVBNJ_G0030916
 protein coding gene Chr6:111040196-111150799 (-)
LP/J MGP_LPJ_G0031042
 protein coding gene Chr6:117465199-117586418 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030950
 protein coding gene Chr6:129396738-129509371 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031609
 protein coding gene Chr6:116000086-116112625 (-)
PWK/PhJ MGP_PWKPhJ_G0029946
 protein coding gene Chr6:110868346-110978656 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029774
 protein coding gene Chr6:114688767-114802403 (-)
WSB/EiJ MGP_WSBEiJ_G0030314
 protein coding gene Chr6:116237137-116349681 (-)



Homology
more
  • Human Ortholog
    VGLL4, vestigial like family member 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VGLL4, vestigial like family member 4
  • Synonyms
    VGL-4
  • Links
    NCBI Gene ID: 9686
    neXtProt AC: NX_Q14135
    UniProt: Q14135

  • Chr Location
    3p25.3-p25.2; chr3:11556067-11771350 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit premature death associated with compensatory cardiac hypertrophy, increased cardiac contractility, and thickening of the aortic and pulmonary valves due to increased cellular proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    10
  • cDNA Data
    11
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030315 Ensembl Gene Model | MGI Sequence Detail 109367 C57BL/6J ±  kb
    transcript ENSMUST00000032459 Ensembl | MGI Sequence Detail 2028 Not Applicable  
    polypeptide ENSMUSP00000032459 Ensembl | MGI Sequence Detail 287 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory