Tg(Mpz)80.2Wra
Transgene Detail

Summary

• Symbol: Tg(Mpz)80.2Wra
• Name: transgene insertion 80.2, Lawrence Wrabetz
• MGI ID: MGI:2447694
• Synonyms: Tg80.2
• Transgene: Tg(Mpz)80.2Wra Location: unknown
• Alliance: Tg(Mpz)80.2Wra page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mpz)80.2Wra expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mpz (MGI:103177)

• Mutation details: The entire Mpz gene (including 6 kb of promoter sequences, all exons and introns, and the natural polyadenylation signal) was used as the transgene. Line 80.2 carries over 31 copies of the integrated transgene and expression is approximately 7.3-fold that of the endogenous protein. (J:78758)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:78758 Wrabetz L, et al., P(0) glycoprotein overexpression causes congenital hypomyelination of peripheral nerves. J Cell Biol. 2000 Mar 6;148(5):1021-34
• All: 2 reference(s)