About   Help   FAQ
Amigo1 Gene Detail
Summary
  • Symbol
    Amigo1
  • Name
    adhesion molecule with Ig like domain 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2653612
    NCBI Gene: 229715
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108093651-108099602 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2653612
 protein coding gene Chr3:108093605-108099602 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027768
 protein coding gene Chr3:109723453-109729404 (+)
A/J MGP_AJ_G0027728
 protein coding gene Chr3:106246847-106252798 (+)
AKR/J MGP_AKRJ_G0027693
 protein coding gene Chr3:108831256-108837207 (+)
BALB/cJ MGP_BALBcJ_G0027740
 protein coding gene Chr3:105948016-105953961 (+)
C3H/HeJ MGP_C3HHeJ_G0027470
 protein coding gene Chr3:109176697-109182648 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028184
 protein coding gene Chr3:113827823-113833774 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025522
 protein coding gene Chr3:102398317-102404263 (+)
CAST/EiJ MGP_CASTEiJ_G0026926
 protein coding gene Chr3:108562029-108567459 (+)
CBA/J MGP_CBAJ_G0027445
 protein coding gene Chr3:117689436-117695387 (+)
DBA/2J MGP_DBA2J_G0027587
 protein coding gene Chr3:105428459-105434410 (+)
FVB/NJ MGP_FVBNJ_G0027555
 protein coding gene Chr3:103315919-103321866 (+)
LP/J MGP_LPJ_G0027694
 protein coding gene Chr3:111143428-111149379 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027585
 protein coding gene Chr3:123759405-123765356 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028239
 protein coding gene Chr3:108431658-108437614 (+)
PWK/PhJ MGP_PWKPhJ_G0026652
 protein coding gene Chr3:105178462-105183896 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026472
 protein coding gene Chr3:106567965-106573467 (+)
WSB/EiJ MGP_WSBEiJ_G0027006
 protein coding gene Chr3:108960116-108966067 (+)



Homology
more
  • Human Ortholog
    AMIGO1, adhesion molecule with Ig like domain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMIGO1, adhesion molecule with Ig like domain 1
  • Synonyms
    ALI2, AMIGO, AMIGO-1
  • Links
    NCBI Gene ID: 57463
    neXtProt AC: NX_Q86WK6
    UniProt: Q86WK6

  • Chr Location
    1p13.3; chr1:109504178-109509738 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show a reduced size of retinal horizontal cell axons with no changes in the size of their dendrites or the ability of both arbors to form connections. The changes in horizontal cell axons are matched by changes in synaptic partner dendrites to stabilize retinal function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    80
  • cDNA Data
    7
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050947 Ensembl Gene Model | MGI Sequence Detail 5952 C57BL/6J ±  kb
transcript ENSMUST00000106656 Ensembl | MGI Sequence Detail 5482 Not Applicable  
polypeptide ENSMUSP00000102267 Ensembl | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 7
    Primer pair 3
    Other 1

    Microarray probesets 6
References
more
  • Summaries
    All 44
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:18891 Ramamoorthy S, et al., Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Biochem J. 1994 Jun 15;300(Pt 3):893-900
  • Latest
    J:347599 Raja R, et al., Insertion of a neomycin selection cassette in the Amigo1 locus alters gene expression in the olfactory epithelium leading to region-specific defects in olfactory receptor neuron development. Genesis. 2024 Apr;62(2):e23594
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory