Sox21 MGI Mouse Gene Detail - MGI:2654070 - SRY (sex determining region Y)-box 21

Symbol

Sox21
Name

SRY (sex determining region Y)-box 21
Synonyms

Sox25

Feature Type

protein coding gene
IDs

MGI:2654070
NCBI Gene: 223227
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr14:118470645-118474442 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 61.92 cM
Mapping Data

1 experiment

SNPs within 2kb

128 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2654070	protein coding gene	Chr14:118470644-118474442 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021649	protein coding gene	Chr14:115807733-115811531 (-)
A/J	MGP_AJ_G0021608	protein coding gene	Chr14:111393058-111396856 (-)
AKR/J	MGP_AKRJ_G0021584	protein coding gene	Chr14:115007381-115011179 (-)
BALB/cJ	MGP_BALBcJ_G0021614	protein coding gene	Chr14:111933272-111937070 (-)
C3H/HeJ	MGP_C3HHeJ_G0021392	protein coding gene	Chr14:114883015-114886813 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022054	protein coding gene	Chr14:120308603-120312401 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019593	protein coding gene	Chr14:107457711-107461526 (-)
CAST/EiJ	MGP_CASTEiJ_G0020908	protein coding gene	Chr14:112718304-112722101 (-)
CBA/J	MGP_CBAJ_G0021360	protein coding gene	Chr14:124923186-124926984 (-)
DBA/2J	MGP_DBA2J_G0021483	protein coding gene	Chr14:111312660-111316458 (-)
FVB/NJ	MGP_FVBNJ_G0021461	protein coding gene	Chr14:109647075-109650878 (-)
LP/J	MGP_LPJ_G0021551	protein coding gene	Chr14:116840694-116844733 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021488	protein coding gene	Chr14:130004077-130007875 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022077	protein coding gene	Chr14:114471787-114475586 (-)
PWK/PhJ	MGP_PWKPhJ_G0020652	protein coding gene	Chr14:108300854-108304642 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020490	protein coding gene	Chr14:110721232-110725030 (-)
WSB/EiJ	MGP_WSBEiJ_G0020963	protein coding gene	Chr14:115275061-115278857 (-)

Human Ortholog

SOX21, SRY-box transcription factor 21

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SOX21, SRY-box transcription factor 21
Synonyms

SOX25
Links

HGNC:11197

NCBI Gene ID: 11166

neXtProt AC: NX_Q9Y651

UniProt: Q9Y651
Chr Location

13q32.1; chr13:94709622-94712545 (-) GRCh38

MGI Vertebrate Homology

Sox21 stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: SOX21
Gene Tree

Sox21

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Phenotype Summary

32 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Sox21
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display cyclic alopecia, epidermal hyperplasia, enlarged sebaceous glands, and hair shaft and cuticle abnormalities.

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All GO Annotations

20
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

850
Tissues

93
cDNA Data

18
Literature Summary

34

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sox21

ZFIN sox21a, sox21b

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS27334.1

Ensembl

ENSMUSG00000061517 (Evidence)
NCBI Gene

223227

			Length	Strain/Species	Flank
genomic	223227	NCBI Gene Model \| MGI Sequence Detail	3798	C57BL/6J	± kb
transcript	NM_177753	RefSeq \| MGI Sequence Detail	3798	C57BL/6
polypeptide	Q811W0	UniProt \| EBI \| MGI Sequence Detail	276	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015427 transcription factor SOX-21

(term hierarchy)
InterPro Domains

IPR009071 High mobility group box domain

IPR036910 High mobility group box domain superfamily

IPR050140 SRY-related HMG-box transcription factors

IPR022097 Transcription factor SOX

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All nucleic 32

Genomic 2

cDNA 18

Primer pair 8

Other 4

Microarray probesets 4

Summaries

All 68

Developmental Gene Expression 34

Gene Ontology 6

Phenotypes 16
Earliest

J:67314 Roix J, et al., Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics. 2001 Feb;157(2):803-15
Latest

J:355488 Erjavec E, et al., Congenital microcoria deletion in mouse links Sox21 dysregulation to disease and suggests a role for TGFB2 in glaucoma and myopia. Am J Hum Genet. 2024 Oct 3;111(10):2265-2282

TSS for Sox21:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130226	Chr14:118474450-118474459 (-)	-13 bp
Tssr130225	Chr14:118474428-118474447 (-)	4 bp
Tssr130224	Chr14:118474404-118474425 (-)	27 bp
Tssr130223	Chr14:118474373-118474382 (-)	64 bp
Tssr130222	Chr14:118474050-118474075 (-)	379 bp
Tssr130221	Chr14:118473628-118473654 (-)	801 bp
Tssr130220	Chr14:118473530-118473557 (-)	898 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24