Ctdsp1 MGI Mouse Gene Detail - MGI:2654470

Symbol

Ctdsp1
Name

CTD small phosphatase 1
Synonyms

SCP1

Feature Type

protein coding gene
IDs

MGI:2654470
NCBI Gene: 227292
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr1:74430668-74436444 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.54 cM
Mapping Data

1 experiment

SNPs within 2kb

178 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2654470	protein coding gene	Chr1:74430625-74436444 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016150	protein coding gene	Chr1:74989894-74996734 (+)
A/J	MGP_AJ_G0016133	protein coding gene	Chr1:72363613-72367883 (+)
AKR/J	MGP_AKRJ_G0016090	protein coding gene	Chr1:74375086-74382691 (+)
BALB/cJ	MGP_BALBcJ_G0016088	protein coding gene	Chr1:72431598-72436765 (+)
C3H/HeJ	MGP_C3HHeJ_G0015919	protein coding gene	Chr1:74708941-74712651 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016541	protein coding gene	Chr1:77905330-77911218 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014262	protein coding gene	Chr1:67950310-67956053 (+)
CAST/EiJ	MGP_CASTEiJ_G0015503	protein coding gene	Chr1:74033301-74037576 (+)
CBA/J	MGP_CBAJ_G0015892	protein coding gene	Chr1:80434250-80438597 (+)
DBA/2J	MGP_DBA2J_G0015993	protein coding gene	Chr1:71696942-71703499 (+)
FVB/NJ	MGP_FVBNJ_G0015996	protein coding gene	Chr1:70877442-70882063 (+)
LP/J	MGP_LPJ_G0016065	protein coding gene	Chr1:76094457-76101502 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016016	protein coding gene	Chr1:83852704-83858008 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016588	protein coding gene	Chr1:74443418-74447738 (+)
PWK/PhJ	MGP_PWKPhJ_G0015290	protein coding gene	Chr1:71148632-71155569 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015068	protein coding gene	Chr1:73815133-73820925 (+)
WSB/EiJ	MGP_WSBEiJ_G0015565	protein coding gene	Chr1:74237043-74241426 (+)

Human Ortholog

CTDSP1, CTD small phosphatase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTDSP1, CTD small phosphatase 1
Synonyms

NIF3, NLI-IF, NLIIF, SCP1
Links

HGNC:21614

NCBI Gene ID: 58190

neXtProt AC: NX_Q9GZU7

UniProt: Q9GZU7
Chr Location

2q35; chr2:218396351-218405941 (+) GRCh38

MGI Vertebrate Homology

Ctdsp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CTDSP1
Gene Tree

Ctdsp1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

2
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Ctdsp1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

26
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

792
Tissues

69
cDNA Data

9
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctdsp1

ZFIN ctdsp1

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All Sequences

53
RefSeq

8
UniProt

3
CCDS

CCDS15048.1

Ensembl

ENSMUSG00000026176 (Evidence)
NCBI Gene

227292

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026176	Ensembl Gene Model \| MGI Sequence Detail	5777	C57BL/6J	± kb
transcript	ENSMUST00000027367	Ensembl \| MGI Sequence Detail	2876	Not Applicable
polypeptide	ENSMUSP00000027367	Ensembl \| MGI Sequence Detail	261	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032125 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR040078 CTD small RNA polymerase II polypeptide A phosphatase-like

IPR011948 Dullard phosphatase domain, eukaryotic

IPR004274 FCP1 homology domain

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR050365 Mitochondrial import inner membrane translocase subunit TIM50

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All nucleic 11

cDNA 9

Primer pair 1

Other 1

Microarray probesets 2

Summaries

All 45

Developmental Gene Expression 6

Gene Ontology 9

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ctdsp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7405	Chr1:74430549-74430556 (+)	-115 bp
Tssr7406	Chr1:74430575-74430636 (+)	-62 bp
Tssr7407	Chr1:74430638-74430654 (+)	-22 bp
Tssr7408	Chr1:74430700-74430709 (+)	37 bp
Tssr7409	Chr1:74430721-74430732 (+)	59 bp
Tssr7410	Chr1:74430736-74430753 (+)	77 bp
Tssr7411	Chr1:74430791-74430843 (+)	149 bp
Tssr7412	Chr1:74430846-74430875 (+)	193 bp
Tssr7413	Chr1:74430899-74430919 (+)	241 bp
Tssr7414	Chr1:74430964-74430988 (+)	308 bp
Tssr7415	Chr1:74431006-74431029 (+)	350 bp
Tssr7416	Chr1:74431031-74431044 (+)	370 bp
Tssr164673	Chr1:74434809-74434837 (+)	4,155 bp
Tssr7418	Chr1:74435715-74435732 (+)	5,056 bp
Tssr164674	Chr1:74436355-74436368 (+)	5,694 bp
Tssr164675	Chr1:74436385-74436396 (+)	5,723 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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