Rbm28 MGI Mouse Gene Detail - MGI:2655711 - RNA binding motif protein 28

Symbol

Rbm28
Name

RNA binding motif protein 28
Synonyms

2810480G15Rik, MGC:12075, MGC:38664

Feature Type

protein coding gene
IDs

MGI:2655711
NCBI Gene: 68272
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:29123572-29164975 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 12.33 cM
Mapping Data

1 experiment

SNPs within 2kb

1279 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2655711	protein coding gene	Chr6:29123572-29165005 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030514	protein coding gene	Chr6:26888197-26931123 (-)
A/J	MGP_AJ_G0030487	protein coding gene	Chr6:25754551-25796514 (-)
AKR/J	MGP_AKRJ_G0030414	protein coding gene	Chr6:26604650-26646336 (-)
BALB/cJ	MGP_BALBcJ_G0030497	protein coding gene	Chr6:25913081-25955098 (-)
C3H/HeJ	MGP_C3HHeJ_G0030210	protein coding gene	Chr6:26606775-26650166 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030951	protein coding gene	Chr6:27681743-27723106 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028162	protein coding gene	Chr6:23961311-24005863 (-)
CAST/EiJ	MGP_CASTEiJ_G0029612	protein coding gene	Chr6:26389796-26432989 (-)
CBA/J	MGP_CBAJ_G0030188	protein coding gene	Chr6:28688242-28731287 (-)
DBA/2J	MGP_DBA2J_G0030332	protein coding gene	Chr6:25700719-25742417 (-)
FVB/NJ	MGP_FVBNJ_G0030286	protein coding gene	Chr6:25454669-25496001 (-)
LP/J	MGP_LPJ_G0030419	protein coding gene	Chr6:27029905-27074053 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030322	protein coding gene	Chr6:31230333-31273346 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030981	protein coding gene	Chr6:26468536-26513109 (-)
PWK/PhJ	MGP_PWKPhJ_G0029326	protein coding gene	Chr6:25233149-25276270 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029162	protein coding gene	Chr6:26192113-26237557 (-)
WSB/EiJ	MGP_WSBEiJ_G0029688	protein coding gene	Chr6:26441867-26487437 (-)

Human Ortholog

RBM28, RNA binding motif protein 28

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBM28, RNA binding motif protein 28
Synonyms

ANES, NOP4
Links

HGNC:21863

NCBI Gene ID: 55131

neXtProt AC: NX_Q9NW13

UniProt: Q9NW13
Chr Location

7q32.1; chr7:128297685-128343908 (-) GRCh38

MGI Vertebrate Homology

Rbm28 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RBM28
Gene Tree

Rbm28

Diseases

1 with human RBM28 associations

				Human Disease	Mouse Models
				alopecia, neurologic defects, and endocrinopathy syndrome IDs alopecia, neurologic defects, and endocrinopathy syndrome DOID:0112244 MESH:C567425 OMIM:612079 ORDO:157954

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

15
Endonuclease-mediated

2
Gene trapped

11
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

25
cDNA Data

124
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rbm28

ZFIN rbm28

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All Sequences

57
RefSeq

6
UniProt

3
CCDS

CCDS51733.1

Ensembl

ENSMUSG00000029701 (Evidence)
NCBI Gene

68272

			Length	Strain/Species	Flank
genomic	68272	NCBI Gene Model \| MGI Sequence Detail	41404	C57BL/6J	± kb
transcript	NM_133925	RefSeq \| MGI Sequence Detail	4201	C57BL/6
polypeptide	Q8CGC6	UniProt \| EBI \| MGI Sequence Detail	750	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013793 RNA-binding protein 28

(term hierarchy)
PDB

1X4H
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR051945 RRM MRD1 RNA Processing and Ribosome Biogenesis

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All nucleic 127

cDNA 124

Primer pair 3

Microarray probesets 7

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MGI:2141434

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:303700 Cajigas I, et al., Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain. Development. 2021 Mar 15;148(6):dev197202

TSS for Rbm28:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr60072	Chr6:29165012-29165013 (-)	-38 bp
Tssr60071	Chr6:29165002-29165007 (-)	-30 bp
Tssr60070	Chr6:29164983-29164998 (-)	-16 bp
Tssr60069	Chr6:29164653-29164706 (-)	295 bp
Tssr60068	Chr6:29160169-29160194 (-)	4,793 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24