Tg(ITGAL-Hhex)2Hro
Transgene Detail

Summary

• Symbol: Tg(ITGAL-Hhex)2Hro
• Name: transgene insertion 2, Robert Hromas
• MGI ID: MGI:2448672
• Synonyms: CD11a/Hex
• Transgene: Tg(ITGAL-Hhex)2Hro Location: unknown
• Alliance: Tg(ITGAL-Hhex)2Hro page

Transgene origin

• Strain of Origin: C3HeB/FeJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ITGAL-Hhex)2Hro expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hhex (MGI:96086)

• Mutation details: A full length Hhex cDNA sequence under regulatory control of the human ITGAL promoter was used to drive transgene expression in thymocytes. Northern and Western blot analysis showed that transgene expression is present in bone marrow, spleen, and thymus. (J:80777)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Seven transgenic founders were created.

References

• Original: J:80777 Mack DL, et al., Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development. Immunology. 2002 Dec;107(4):444-51
• All: 1 reference(s)