Ang4 MGI Mouse Gene Detail - MGI:2656551 - angiogenin, ribonuclease A family, member 4

Symbol

Ang4
Name

angiogenin, ribonuclease A family, member 4
Synonyms

Rnase5d

Feature Type

protein coding gene
IDs

MGI:2656551
NCBI Gene: 219033
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr14:52001349-52011047 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.66 cM, cytoband B-C1
Mapping Data

2 experiments

SNPs within 2kb

567 from dbSNP Build 142
Strain Annotations

8

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2656551	protein coding gene	Chr14:52001335-52011047 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021279	protein coding gene	Chr14:45749688-45771015 (-)
A/J	MGP_AJ_G0021236	protein coding gene	Chr14:44555714-44563929 (-)
AKR/J	MGP_AKRJ_G0021210	protein coding gene	Chr14:46183683-46197292 (-)
BALB/cJ	MGP_BALBcJ_G0021240	protein coding gene	Chr14:44666421-44680513 (-)
C3H/HeJ	MGP_C3HHeJ_G0021020	protein coding gene	Chr14:45984405-45991119 (-)
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0020987	protein coding gene	Chr14:49200526-49211960 (-)
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0021183	protein coding gene	Chr14:46320178-46329801 (-)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

ANG, angiogenin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANG, angiogenin
Synonyms

ALS9, HEL168, RAA1, RNASE4, RNASE5
Links

HGNC:483

NCBI Gene ID: 283

neXtProt AC: NX_P03950

UniProt: P03950
Chr Location

14q11.2; chr14:20684177-20698971 (+) GRCh38

MGI Vertebrate Homology

Ang4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANG
Gene Tree

Ang4

Diseases

6 with human ANG associations

				Human Disease	Mouse Models
				amyotrophic lateral sclerosis IDs amyotrophic lateral sclerosis DOID:332 ICD10CM:G12.21 ICD9CM:335.20 KEGG:05014 MESH:D000690 NCI:C34373 OMIM:PS105400 ORDO:803 UMLS_CUI:C0002736
				amyotrophic lateral sclerosis type 9 IDs amyotrophic lateral sclerosis type 9 DOID:0060200 OMIM:611895
				diabetic retinopathy IDs diabetic retinopathy DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 UMLS_CUI:C0011884
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Genomic Mutations

1 involving Ang4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available

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All GO Annotations

51
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

19
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

25
RefSeq

2
UniProt

2
CCDS

CCDS36911.1

Ensembl

ENSMUSG00000060615 (Evidence)
NCBI Gene

219033

			Length	Strain/Species	Flank
genomic	219033	NCBI Gene Model \| MGI Sequence Detail	9699	C57BL/6J	± kb
transcript	NM_177544	RefSeq \| MGI Sequence Detail	695	C57BL/6
polypeptide	Q3TMQ6	UniProt \| EBI \| MGI Sequence Detail	144	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000033303 angiogenin-4

(term hierarchy)
PDB

2J4T
EC

3.1.27.-
InterPro Domains

IPR001427 Pancreatic ribonuclease

IPR023411 Ribonuclease A, active site

IPR023412 Ribonuclease A-domain

IPR036816 Ribonuclease A-like domain superfamily

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All nucleic 19

cDNA 19

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 5
Earliest

J:82368 Hooper LV, et al., Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol. 2003 Mar;4(3):269-73
Latest

J:333936 Hu A, et al., Ang1 and Ang4 differentially affect colitis and carcinogenesis in an AOM-DSS mouse model. PLoS One. 2023;18(3):e0281529

TSS for Ang4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128438	Chr14:52011035-52011053 (-)	3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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