Dtx3l MGI Mouse Gene Detail - MGI:2656973 - deltex 3-like, E3 ubiquitin ligase

Symbol

Dtx3l
Name

deltex 3-like, E3 ubiquitin ligase

Feature Type

protein coding gene
IDs

MGI:2656973
NCBI Gene: 209200
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr16:35746885-35759397 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 25.43 cM
Mapping Data

2 experiments

SNPs within 2kb

237 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2656973	protein coding gene	Chr16:35746881-35759521 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022773	protein coding gene	Chr16:34278395-34291844 (-)
A/J	MGP_AJ_G0022738	protein coding gene	Chr16:32616216-32629396 (-)
AKR/J	MGP_AKRJ_G0022711	protein coding gene	Chr16:33758705-33772312 (-)
BALB/cJ	MGP_BALBcJ_G0022740	protein coding gene	Chr16:32739393-32751930 (-)
C3H/HeJ	MGP_C3HHeJ_G0022505	protein coding gene	Chr16:33887265-33899786 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023189	protein coding gene	Chr16:35013145-35027492 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020707	protein coding gene	Chr16:32971563-32984284 (-)
CAST/EiJ	MGP_CASTEiJ_G0022033	protein coding gene	Chr16:34114874-34127467 (-)
CBA/J	MGP_CBAJ_G0022475	protein coding gene	Chr16:36437888-36450404 (-)
DBA/2J	MGP_DBA2J_G0022608	protein coding gene	Chr16:32440394-32452918 (-)
FVB/NJ	MGP_FVBNJ_G0022583	protein coding gene	Chr16:32437219-32449735 (-)
LP/J	MGP_LPJ_G0022675	protein coding gene	Chr16:34009479-34022005 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022602	protein coding gene	Chr16:35709500-35722683 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023201	protein coding gene	Chr16:33815363-33827979 (-)
PWK/PhJ	MGP_PWKPhJ_G0021774	protein coding gene	Chr16:32851779-32864371 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021605	protein coding gene	Chr16:33631589-33646889 (-)
WSB/EiJ	MGP_WSBEiJ_G0022077	protein coding gene	Chr16:33741385-33756112 (-)

Human Ortholog

DTX3L, deltex E3 ubiquitin ligase 3L

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DTX3L, deltex E3 ubiquitin ligase 3L
Synonyms

BBAP, RNF143
Links

HGNC:30323

NCBI Gene ID: 151636

neXtProt AC: NX_Q8TDB6

UniProt: Q8TDB6
Chr Location

3q21.1; chr3:122564338-122575203 (+) GRCh38

MGI Vertebrate Homology

Dtx3l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DTX3L
Gene Tree

Dtx3l

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

4
Gene trapped

2
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

67
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

54
cDNA Data

49
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

3
UniProt

2
CCDS

CCDS37325.1

Ensembl

ENSMUSG00000049502 (Evidence)
NCBI Gene

209200

			Length	Strain/Species	Flank
genomic	209200	NCBI Gene Model \| MGI Sequence Detail	12513	C57BL/6J	± kb
transcript	NM_001013371	RefSeq \| MGI Sequence Detail	5181	C57BL/6
polypeptide	Q3UIR3	UniProt \| EBI \| MGI Sequence Detail	748	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006723 E3 ubiquitin-protein ligase DTX3L

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR039396 Deltex, C-terminal

IPR039399 Deltex, C-terminal domain superfamily

IPR039398 Deltex family

IPR048418 DTX3L, alpha/beta domain

IPR048409 DTX3L, KH-like domain

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site
GlyGen

Q3UIR3 1 site, 1 O-linked glycan (1 site)

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All nucleic 50

cDNA 50

Microarray probesets 4

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MGI:3035479

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 7
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dtx3l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140973	Chr16:35760107-35760132 (-)	-723 bp
Tssr140972	Chr16:35760078-35760101 (-)	-693 bp
Tssr140971	Chr16:35759452-35759479 (-)	-69 bp
Tssr140970	Chr16:35759422-35759444 (-)	-36 bp
Tssr140969	Chr16:35759311-35759349 (-)	67 bp
Tssr140968	Chr16:35759282-35759308 (-)	102 bp
Tssr140967	Chr16:35759255-35759278 (-)	130 bp
Tssr140966	Chr16:35753137-35753148 (-)	6,254 bp
Tssr140965	Chr16:35753099-35753110 (-)	6,292 bp
Tssr140964	Chr16:35752898-35752918 (-)	6,489 bp
Tssr140963	Chr16:35751391-35751406 (-)	7,998 bp
Tssr140962	Chr16:35749253-35749273 (-)	10,134 bp
Tssr140961	Chr16:35749214-35749235 (-)	10,172 bp
Tssr140960	Chr16:35747321-35747325 (-)	12,074 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24