Btla MGI Mouse Gene Detail - MGI:2658978 - B and T lymphocyte associated

Symbol

Btla
Name

B and T lymphocyte associated

Feature Type

protein coding gene
IDs

MGI:2658978
NCBI Gene: 208154
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr16:45043121-45073258 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 29.52 cM
Mapping Data

2 experiments

SNPs within 2kb

1122 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2658978	protein coding gene	Chr16:45043121-45078033 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022850	protein coding gene	Chr16:44001705-44032838 (+)
A/J	MGP_AJ_G0022815	protein coding gene	Chr16:42027017-42055156 (+)
AKR/J	MGP_AKRJ_G0022787	protein coding gene	Chr16:43410429-43439610 (+)
BALB/cJ	MGP_BALBcJ_G0022816	protein coding gene	Chr16:42033879-42063650 (+)
C3H/HeJ	MGP_C3HHeJ_G0022580	protein coding gene	Chr16:43562339-43588770 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023263	protein coding gene	Chr16:44992988-45023506 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020777	protein coding gene	Chr16:42420822-42448876 (+)
CAST/EiJ	MGP_CASTEiJ_G0022105	protein coding gene	Chr16:43748645-43777422 (+)
CBA/J	MGP_CBAJ_G0022551	protein coding gene	Chr16:46899133-46928516 (+)
DBA/2J	MGP_DBA2J_G0022683	protein coding gene	Chr16:41770491-41797668 (+)
FVB/NJ	MGP_FVBNJ_G0022659	protein coding gene	Chr16:41692412-41719060 (+)
LP/J	MGP_LPJ_G0022751	protein coding gene	Chr16:43736192-43763634 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022677	protein coding gene	Chr16:46307743-46336372 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023278	protein coding gene	Chr16:43426425-43454141 (+)
PWK/PhJ	MGP_PWKPhJ_G0021845	protein coding gene	Chr16:42133553-42162419 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021676	protein coding gene	Chr16:43349356-43380712 (+)
WSB/EiJ	MGP_WSBEiJ_G0022150	protein coding gene	Chr16:43516936-43546104 (+)

Human Ortholog

BTLA, B and T lymphocyte associated

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BTLA, B and T lymphocyte associated
Synonyms

BTLA1, CD272
Links

HGNC:21087

NCBI Gene ID: 151888

neXtProt AC: NX_Q7Z6A9

UniProt: Q7Z6A9
Chr Location

3q13.2; chr3:112463966-112499624 (-) GRCh38

MGI Vertebrate Homology

Btla stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BTLA
Gene Tree

Btla

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Phenotype Summary

13 phenotypes from 3 alleles in 4 genetic backgrounds
3 phenotypes from multigenic genotypes
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

8
Targeted

6
Incidental Mutations

APF
Find Mice (IMSR)

30 strains or lines available

Targeted inactivation of this gene leads to increased T cell activation. Homozygotes for a null allele show altered peripheral T cell anergy. Homozygotes for a different null allele show enhanced specific antibody responses, increased susceptibility to EAE, and prolonged allograft survival.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

9
cDNA Data

32
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

12
UniProt

5
CCDS

CCDS28195.1, CCDS28196.1

Ensembl

ENSMUSG00000052013 (Evidence)
NCBI Gene

208154

			Length	Strain/Species	Flank
genomic	208154	NCBI Gene Model \| MGI Sequence Detail	30138	C57BL/6J	± kb
transcript	NM_001037719	RefSeq \| MGI Sequence Detail	3235	C57BL/6
polypeptide	Q7TSA3	UniProt \| EBI \| MGI Sequence Detail	306	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001284 B- and T-lymphocyte attenuator

(term hierarchy)
PDB

1XAU
InterPro Domains

IPR039257 B- and T-lymphocyte attenuator

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype
GlyGen

Q7TSA3 6 sites

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All nucleic 33

cDNA 32

Primer pair 1

Microarray probesets 3

Summaries

All 68

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 37
Earliest

J:84084 Watanabe N, et al., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003 Jul;4(7):670-9
Latest

J:337669 Seo GY, et al., Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection. Sci Immunol. 2022 Jul 29;7(73):eabm6931

TSS for Btla:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138611	Chr16:45044302-45044314 (+)	1,187 bp
Tssr138612	Chr16:45044437-45044448 (+)	1,322 bp
Tssr138613	Chr16:45044475-45044486 (+)	1,360 bp
Tssr138614	Chr16:45044491-45044502 (+)	1,376 bp
Tssr138615	Chr16:45044507-45044532 (+)	1,399 bp
Tssr138616	Chr16:45044534-45044555 (+)	1,424 bp
Tssr138617	Chr16:45044688-45044709 (+)	1,578 bp
Tssr138618	Chr16:45044720-45044727 (+)	1,603 bp
Tssr138619	Chr16:45044945-45044956 (+)	1,830 bp
Tssr138620	Chr16:45045308-45045321 (+)	2,194 bp
Tssr138621	Chr16:45045340-45045351 (+)	2,225 bp
Tssr138622	Chr16:45047630-45047672 (+)	4,530 bp
Tssr138623	Chr16:45065339-45065342 (+)	22,220 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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