Gucy1b2 MGI Mouse Gene Detail - MGI:2660873 - guanylate cyclase 1, soluble, beta 2

Symbol

Gucy1b2
Name

guanylate cyclase 1, soluble, beta 2

Feature Type

protein coding gene
IDs

MGI:2660873
NCBI Gene: 239134
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:62630125-62693738 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 33.21 cM
Mapping Data

1 experiment

SNPs within 2kb

2167 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2660873	protein coding gene	Chr14:62610384-62693745 (-)
129S1/SvImJ	ENSMUSG00200041660	protein coding gene	Chr14:51226566-51290237 (-)
A/J	ENSMUSG00195029008	protein coding gene	Chr14:51405867-51469746 (-)
AKR/J	ENSMUSG00220028907	protein coding gene	Chr14:50753184-50817074 (-)
BALB/cJ	ENSMUSG00180051291	protein coding gene	Chr14:51027803-51091670 (-)
C3H/HeJ	ENSMUSG00175034247	protein coding gene	Chr14:52762341-52826026 (-)
C57BL/6NJ	ENSMUSG00215045160	protein coding gene	Chr14:50957176-51020799 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019390	protein coding gene	Chr14:53535026-53601517 (-)
CAST/EiJ	ENSTCUG00005035783	protein coding gene	Chr14:52681852-52746951 (-)
CBA/J	ENSMUSG00210036443	protein coding gene	Chr14:51393800-51457678 (-)
DBA/2J	ENSMUSG00185029625	protein coding gene	Chr14:56560130-56623817 (-)
FVB/NJ	ENSMUSG00205019141	protein coding gene	Chr14:50912831-50976726 (-)
JF1/MsJ	ENSUMUG00000025863	protein coding gene	Chr14:67751749-67817728 (-)
LP/J	ENSMUSG00230032136	protein coding gene	Chr14:68589773-68653436 (-)
NOD/ShiLtJ	ENSMUSG00190031680	protein coding gene	Chr14:51190194-51254056 (-)
NZO/HlLtJ	ENSMUSG00225043979	protein coding gene	Chr14:58931318-58994932 (-)
PWK/PhJ	ENSLUMG00010039245	protein coding gene	Chr14:50639637-50707203 (-)
SPRET/EiJ	ENSMSPG00010029864	protein coding gene	Chr14:54108013-54168105 (-)
WSB/EiJ	ENSIUOG00005036266	protein coding gene	Chr14:50631763-50704568 (-)

Human Ortholog

GUCY1B2, guanylate cyclase 1 soluble subunit beta 2 (pseudogene)

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GUCY1B2, guanylate cyclase 1 soluble subunit beta 2 (pseudogene)
Synonyms

GC-SB2, GUCY1B2P
Links

HGNC:4686

NCBI Gene ID: 2974
Chr Location

13q14.3; chr13:50994505-51080862 (-) GRCh38

MGI Vertebrate Homology

Gucy1b2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GUCY1B2
Gene Tree

Gucy1b2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotypes from multigenic genotypes
8 phenotype references

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

1 involving Gucy1b2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

Mice homozygous for a knock-out allele exhibit a normal hyperventilation response to a 10% oxygen environment.

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

696
Tissues

97
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gucy1b2

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All Sequences

51
RefSeq

12
UniProt

7
CCDS

CCDS27190.1, CCDS56962.1

Ensembl

ENSMUSG00000021933 (Evidence)
NCBI Gene

239134

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021933	Ensembl Gene Model \| MGI Sequence Detail	63614	C57BL/6J	± kb
transcript	ENSMUST00000022501	Ensembl \| MGI Sequence Detail	2711	Not Applicable
polypeptide	ENSMUSP00000022501	Ensembl \| MGI Sequence Detail	824	Not Applicable

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UniProt

7 Sequences
EC

4.6.1.2
InterPro Domains

IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase

IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site

IPR011645 Haem NO binding associated

IPR042463 Haem NO binding associated domain superfamily

IPR011644 Heme NO-binding

IPR038158 H-NOX domain superfamily

IPR024096 NO signalling/Golgi transport ligand-binding domain superfamily

IPR029787 Nucleotide cyclase

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 1

Summaries

All 33

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 8
Earliest

J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
Latest

J:307157 Koike K, et al., Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide. Neuron. 2021 Jun;109:1-16

TSS for Gucy1b2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129108	Chr14:62651942-62651956 (-)	41,789 bp
Tssr129107	Chr14:62651728-62651776 (-)	41,986 bp
Tssr129106	Chr14:62649262-62649266 (-)	44,474 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24