Gucy1a2 Gene Detail

Summary

• Symbol
  Gucy1a2
• Name
  guanylate cyclase 1, soluble, alpha 2
• Synonyms
  6330407I18Rik, A230060L24Rik

• Feature Type
  protein coding gene
• IDs
  MGI:2660877
  NCBI Gene: 234889
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr9:3532778-3894736 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 2.14 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  8171 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2660877	protein coding gene	Chr9:3532349-3905791 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034307	protein coding gene	Chr9:228928-586743 (+)
A/J	MGP_AJ_G0034284	protein coding gene	Chr9:373340-767339 (+)
AKR/J	MGP_AKRJ_G0034214	protein coding gene	Chr9:264597-623574 (+)
BALB/cJ	MGP_BALBcJ_G0034278	protein coding gene	Chr9:223893-579829 (+)
C3H/HeJ	MGP_C3HHeJ_G0033990	protein coding gene	Chr9:375091-750380 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034800	protein coding gene	Chr9:332078-721539 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031738	protein coding gene	Chr9:151317-422242 (+)
CAST/EiJ	MGP_CASTEiJ_G0033317	protein coding gene	Chr9:486333-834869 (+)
CBA/J	MGP_CBAJ_G0033962	protein coding gene	Chr9:230200-630100 (+)
DBA/2J	MGP_DBA2J_G0034119	protein coding gene	Chr9:378284-726721 (+)
FVB/NJ	MGP_FVBNJ_G0034064	protein coding gene	Chr9:214040-565947 (+)
LP/J	MGP_LPJ_G0034206	protein coding gene	Chr9:232867-610558 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034108	protein coding gene	Chr9:399249-931337 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034819	protein coding gene	Chr9:210855-598146 (+)
PWK/PhJ	MGP_PWKPhJ_G0033021	protein coding gene	Chr9:507022-867389 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032858	protein coding gene	Chr9:526973-871280 (+)
WSB/EiJ	MGP_WSBEiJ_G0033433	protein coding gene	Chr9:233974-610665 (+)

Homology

• Human Ortholog
  GUCY1A2, guanylate cyclase 1 soluble subunit alpha 2

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  GUCY1A2, guanylate cyclase 1 soluble subunit alpha 2
  
• Synonyms
  GC-SA2, GUC1A2
• Links
  HGNC:4684

  NCBI Gene ID: 2977

  neXtProt AC: NX_P33402

  UniProt: P33402

  
  
• Chr Location
  11q22.3; chr11:106674019-107018476 (-)  GRCh38

---

• MGI Vertebrate Homology
  Gucy1a2 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: GUCY1A2
• Gene Tree
  Gucy1a2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 1 genetic background
  8 phenotype references
  

• All Mutations and Alleles
  6
• Endonuclease-mediated
  2
• Targeted
  4
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  36 strains or lines available

Mice homozygous for a null mutation display normal blood vessel and platelet physiology.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  8
• GO References
  3

Expression

• Assay Results
  802
• Tissues
  96
• cDNA Data
  19
• Literature Summary
  2

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase gucy1a2
  ZFIN gucy1a2

Sequences &
Gene Models

• All Sequences
  44
• RefSeq
  5
• UniProt
  3
• CCDS
  CCDS40526.1

• Ensembl
  ENSMUSG00000041624 (Evidence)
• NCBI Gene
  234889

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000041624	Ensembl Gene Model | MGI Sequence Detail	361959	C57BL/6J
transcript	ENSMUST00000115733	Ensembl | MGI Sequence Detail	2243	Not Applicable
polypeptide	ENSMUSP00000111398	Ensembl | MGI Sequence Detail	730	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• EC
  4.6.1.2
• InterPro Domains
  IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
  IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
  IPR011645 Haem NO binding associated
  IPR042463 Haem NO binding associated domain superfamily
  IPR011644 Heme NO-binding
  IPR038158 H-NOX domain superfamily
  IPR024096 NO signalling/Golgi transport ligand-binding domain superfamily
  IPR029787 Nucleotide cyclase
• GlyGen
  F8VQK3 4 sites, 1 O-linked glycan (4 sites)

Molecular
Reagents

• All nucleic 21

  cDNA 19

  Primer pair 2

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:1917960, MGI:2444229

References

• Summaries
  All 33

  Developmental Gene Expression 2

  Gene Ontology 3

  Phenotypes 8
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Gucy1a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83619	Chr9:3532295-3532354 (+)	-453 bp
Tssr83620	Chr9:3532360-3532448 (+)	-374 bp