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Or8a1 Pseudogene Detail
Summary
  • Symbol
    Or8a1
  • Name
    olfactory receptor family 8 subfamily A member 1
  • Synonyms
    GA_x6K02T2PVTD-31408136-31407207, M71, MOR171-2, Olfr151
Location &
Maps
more
  • Sequence Map
    Chr9:37641273-37642357 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2661338
 polymorphic pseudogene Chr9:37641273-37642400 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    OR8A1, olfactory receptor family 8 subfamily A member 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OR8A1, olfactory receptor family 8 subfamily A member 1
  • Synonyms
    OR11-318, OST025
  • Links
    NCBI Gene ID: 390275
    neXtProt AC: NX_Q8NGG7
    UniProt: Q8NGG7

  • Chr Location
    11q24.2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 15 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Deletion of the coding region causes olfactory sensory neurons to coexpress other odorant receptor (ORs) that function in axonal identity. A drastic reduction in OR protein level causes axonal coalescence into new remote glomeruli. Chimeric ORs and ORs with minor mutations preclude axon outgrowth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    3
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 406176 NCBI Gene Model | MGI Sequence Detail 1085 C57BL/6J ±  kb
    transcript NM_207664 RefSeq | MGI Sequence Detail 1086 Not Specified  
    polypeptide Q60893 UniProt | EBI | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 4
      Other 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:7276791
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 45
    • Earliest
      J:22205 Ressler KJ, et al., Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell. 1994 Dec 30;79(7):1245-55
    • Latest
      J:349562 Shayya HJ, et al., ER stress transforms random olfactory receptor choice into axon targeting precision. Cell. 2022 Oct 13;185(21):3896-3912.e22
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory