Rtn4rl1 MGI Mouse Gene Detail - MGI:2661375 - reticulon 4 receptor-like 1

Symbol

Rtn4rl1
Name

reticulon 4 receptor-like 1
Synonyms

Ngr3, Ngrh2, Ngrl2

Feature Type

protein coding gene
IDs

MGI:2661375
NCBI Gene: 237847
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:75084819-75158595 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.76 cM
Mapping Data

1 experiment

SNPs within 2kb

1610 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2661375	protein coding gene	Chr11:75084609-75158595 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018707	protein coding gene	Chr11:75930340-76008341 (+)
A/J	MGP_AJ_G0018673	protein coding gene	Chr11:73108147-73183170 (+)
AKR/J	MGP_AKRJ_G0018643	protein coding gene	Chr11:75321424-75398119 (+)
BALB/cJ	MGP_BALBcJ_G0018647	protein coding gene	Chr11:73477423-73551228 (+)
C3H/HeJ	MGP_C3HHeJ_G0018460	protein coding gene	Chr11:75337290-75410932 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019098	protein coding gene	Chr11:78303305-78383130 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016733	protein coding gene	Chr11:70122259-70195416 (+)
CAST/EiJ	MGP_CASTEiJ_G0018014	protein coding gene	Chr11:75723681-75802660 (+)
CBA/J	MGP_CBAJ_G0018430	protein coding gene	Chr11:81739690-81813282 (+)
DBA/2J	MGP_DBA2J_G0018539	protein coding gene	Chr11:72714367-72792953 (+)
FVB/NJ	MGP_FVBNJ_G0018529	protein coding gene	Chr11:72277753-72352861 (+)
LP/J	MGP_LPJ_G0018610	protein coding gene	Chr11:76521089-76597471 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018555	protein coding gene	Chr11:82329217-82406393 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019138	protein coding gene	Chr11:75509031-75589642 (+)
PWK/PhJ	MGP_PWKPhJ_G0017785	protein coding gene	Chr11:73408904-73483722 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017576	protein coding gene	Chr11:75079928-75161722 (+)
WSB/EiJ	MGP_WSBEiJ_G0018067	protein coding gene	Chr11:75327827-75405405 (+)

Human Ortholog

RTN4RL1, reticulon 4 receptor like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RTN4RL1, reticulon 4 receptor like 1
Synonyms

NgR3, NGRH2
Links

HGNC:21329

NCBI Gene ID: 146760

neXtProt AC: NX_Q86UN2

UniProt: Q86UN2
Chr Location

17p13.3; chr17:1934677-2025334 (-) GRCh38

MGI Vertebrate Homology

Rtn4rl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RTN4RL1
Gene Tree

Rtn4rl1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Targeted

3
Genomic Mutations

2 involving Rtn4rl1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display fatty change in the liver, bile duct lesions in females and hepatocytes with enlarged vacuoles and nuclei in the male.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

817
Tissues

72
cDNA Data

25
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rtn4rl1

ZFIN rtn4rl1b

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All Sequences

34
RefSeq

4
UniProt

1
CCDS

CCDS25043.1

Ensembl

ENSMUSG00000045287 (Evidence)
NCBI Gene

237847

			Length	Strain/Species	Flank
genomic	237847	NCBI Gene Model \| MGI Sequence Detail	73777	C57BL/6J	± kb
transcript	NM_177708	RefSeq \| MGI Sequence Detail	3308	C57BL/6
polypeptide	Q8K0S5	UniProt \| EBI \| MGI Sequence Detail	445	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014351 reticulon-4 receptor-like 1

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR050328 Multifunctional Developmental and Immune Receptor
GlyGen

Q8K0S5 3 sites, 4 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 28

cDNA 25

Primer pair 3

Microarray probesets 3

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MGI:2669799

Summaries

All 48

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:313762 Bakhuraysah MM, et al., B-cells expressing NgR1 and NgR3 are localized to EAE-induced inflammatory infiltrates and are stimulated by BAFF. Sci Rep. 2021 Feb 3;11(1):2890

TSS for Rtn4rl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102931	Chr11:75084623-75084690 (+)	-162 bp
Tssr102932	Chr11:75084694-75084703 (+)	-120 bp
Tssr102933	Chr11:75084817-75084824 (+)	2 bp
Tssr102934	Chr11:75097653-75097658 (+)	12,837 bp
Tssr102935	Chr11:75104929-75104953 (+)	20,122 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24