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Adap2 Gene Detail
Summary
  • Symbol
    Adap2
  • Name
    ArfGAP with dual PH domains 2
  • Synonyms
    Centa2, centaurin alpha 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2663075
    NCBI Gene: 216991
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:80044931-80069784 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 47.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    752 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2663075
 protein coding gene Chr11:80044869-80071449 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018807
 protein coding gene Chr11:81300896-81325640 (+)
A/J MGP_AJ_G0018774
 protein coding gene Chr11:78177634-78202778 (+)
AKR/J MGP_AKRJ_G0018744
 protein coding gene Chr11:80526624-80551643 (+)
BALB/cJ MGP_BALBcJ_G0018747
 protein coding gene Chr11:78565048-78590013 (+)
C3H/HeJ MGP_C3HHeJ_G0018561
 protein coding gene Chr11:80571457-80596185 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019199
 protein coding gene Chr11:83793944-83822126 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016833
 protein coding gene Chr11:75107766-75132717 (+)
CAST/EiJ MGP_CASTEiJ_G0018116
 protein coding gene Chr11:81055725-81081823 (+)
CBA/J MGP_CBAJ_G0018532
 protein coding gene Chr11:87445808-87470630 (+)
DBA/2J MGP_DBA2J_G0018640
 protein coding gene Chr11:77733116-77759248 (+)
FVB/NJ MGP_FVBNJ_G0018629
 protein coding gene Chr11:77300803-77326812 (+)
LP/J MGP_LPJ_G0018710
 protein coding gene Chr11:81817032-81841806 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018656
 protein coding gene Chr11:87728854-87754743 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019239
 protein coding gene Chr11:80775812-80800805 (+)
PWK/PhJ MGP_PWKPhJ_G0017886
 protein coding gene Chr11:78536522-78563358 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017677
 protein coding gene Chr11:80362552-80389456 (+)
WSB/EiJ MGP_WSBEiJ_G0018168
 protein coding gene Chr11:80607218-80631995 (+)



Homology
more
  • Human Ortholog
    ADAP2, ArfGAP with dual PH domains 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAP2, ArfGAP with dual PH domains 2
  • Synonyms
    CENTA2, cent-b, HSA272195
  • Links
    NCBI Gene ID: 55803
    neXtProt AC: NX_Q9NPF8
    UniProt: Q9NPF8

  • Chr Location
    17q11.2; chr17:30906344-30959322 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    27
  • cDNA Data
    7
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020709 Ensembl Gene Model | MGI Sequence Detail 24854 C57BL/6J ±  kb
transcript ENSMUST00000021050 Ensembl | MGI Sequence Detail 1785 Not Applicable  
polypeptide ENSMUSP00000021050 Ensembl | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    Genomic 1
    cDNA 7
    Primer pair 2
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:211673 Venturin M, et al., ADAP2 in heart development: a candidate gene for the occurrence of cardiovascular malformations in NF1 microdeletion syndrome. J Med Genet. 2014 Jul;51(7):436-43
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory