Tg(Plp1-cre/ERT2)1Ueli
Transgene Detail

Summary

• Symbol: Tg(Plp1-cre/ERT2)1Ueli
• Name: transgene insertion 1, Ueli Suter
• MGI ID: MGI:2663093
• Synonyms: PLP-CreERT2, PLP/Cre-ERT2, Tg(Plp1-cre/ESR1)1Ueli
• Transgene: Tg(Plp1-cre/ERT2)1Ueli Location: unknown
• Alliance: Tg(Plp1-cre/ERT2)1Ueli page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Plp1-cre/ERT2)1Ueli expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Plp1 (MGI:97623)

• Mutation details: The transgene consists of a mouse Plp promoter region (exons 1 and 2) and a cre-ESR1 cassette. The human ESR1 sequence is mutated at G400V, M543A, and L540A in the ligand-binding domain to allow activation by 4-hydroxytamoxifen (OHT) and ICI 182,780. 15 kb of mouse Plp promoter sequences drive transgene expression in oligodendrocytes and Schwann cells. (J:83361)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Plp1 (mouse) Summary of all recombinase alleles driven by Plp1. Comparative matrix view of recombinase activities Alliance mouse Plp1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:83361 Leone DP, et al., Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Mol Cell Neurosci. 2003 Apr;22(4):430-40
• All: 56 reference(s)