About   Help   FAQ
Zc3h3 Gene Detail
Summary
  • Symbol
    Zc3h3
  • Name
    zinc finger CCCH type containing 3
  • Synonyms
    Smicl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2663721
    NCBI Gene: 223642
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:75626279-75713764 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1692 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2663721
 protein coding gene Chr15:75626279-75713772 (-)
129S1/SvImJ ENSMUSG00200051783
 protein coding gene Chr15:72743756-72831241 (-)
A/J ENSMUSG00195046918
 protein coding gene Chr15:72718167-72805652 (-)
AKR/J ENSMUSG00220047545
 protein coding gene Chr15:72729223-72816704 (-)
BALB/cJ ENSMUSG00180045683
 protein coding gene Chr15:72544899-72632388 (-)
C3H/HeJ ENSMUSG00175049414
 protein coding gene Chr15:72906767-72994253 (-)
C57BL/6NJ ENSMUSG00215048052
 protein coding gene Chr15:72635310-72722801 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019897
 protein coding gene Chr15:69711924-69798332 (-)
CAST/EiJ ENSTCUG00005043454
 protein coding gene Chr15:72248373-72336154 (-)
CBA/J ENSMUSG00210034231
 protein coding gene Chr15:72682066-72769555 (-)
DBA/2J ENSMUSG00185049652
 protein coding gene Chr15:72660754-72748249 (-)
FVB/NJ ENSMUSG00205048059
 protein coding gene Chr15:72411453-72498940 (-)
JF1/MsJ ENSUMUG00000054448
 protein coding gene Chr15:72315748-72403615 (-)
LP/J ENSMUSG00230051897
 protein coding gene Chr15:76024754-76112240 (-)
NOD/ShiLtJ ENSMUSG00190028860
 protein coding gene Chr15:72666342-72752497 (-)
NZO/HlLtJ ENSMUSG00225052348
 protein coding gene Chr15:76331171-76417332 (-)
PWK/PhJ ENSLUMG00010044260
 protein coding gene Chr15:72596470-72684571 (-)
SPRET/EiJ ENSMSPG00010050144
 protein coding gene Chr15:74221548-74309153 (-)
WSB/EiJ ENSIUOG00005049208
 protein coding gene Chr15:72723485-72809682 (-)



Homology
more
  • Human Ortholog
    ZC3H3, zinc finger CCCH-type containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZC3H3, zinc finger CCCH-type containing 3
  • Synonyms
    SMICL, ZC3HDC3
  • Links
    NCBI Gene ID: 23144
    UniProt: Q8IXZ2

  • Chr Location
    8q24.3; chr8:143437655-143541455 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    650
  • Tissues
    32
  • cDNA Data
    42
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000075600 Ensembl Gene Model | MGI Sequence Detail 87486 C57BL/6J ±  kb
transcript ENSMUST00000100538 Ensembl | MGI Sequence Detail 3362 Not Applicable  
polypeptide ENSMUSP00000098106 Ensembl | MGI Sequence Detail 950 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 42

    Microarray probesets 4
References
more
  • Summaries
    All 65
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 9
    Phenotypes 33
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory