About   Help   FAQ
Cngb1 Gene Detail
Summary
  • Symbol
    Cngb1
  • Name
    cyclic nucleotide gated channel beta 1
  • Synonyms
    BC016201, Cngb1, Cngb1b, MGC:27656
  • Feature Type
    protein coding gene
  • IDs
    MGI:2664102
    NCBI Gene: 333329
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95965673-96033213 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 47.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2664102
 protein coding gene Chr8:95965671-96033213 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033981
 protein coding gene Chr8:96712844-96787041 (-)
A/J MGP_AJ_G0033964
 protein coding gene Chr8:92930021-92999883 (-)
AKR/J MGP_AKRJ_G0033890
 protein coding gene Chr8:95454398-95525008 (-)
BALB/cJ MGP_BALBcJ_G0033956
 protein coding gene Chr8:93005411-93077768 (-)
C3H/HeJ MGP_C3HHeJ_G0033666
 protein coding gene Chr8:96187283-96258256 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034477
 protein coding gene Chr8:100240493-100314661 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031418
 protein coding gene Chr8:86727314-86796759 (-)
CAST/EiJ MGP_CASTEiJ_G0032998
 protein coding gene Chr8:95777901-95847969 (-)
CBA/J MGP_CBAJ_G0033642
 protein coding gene Chr8:103524518-103604903 (-)
DBA/2J MGP_DBA2J_G0033796
 protein coding gene Chr8:92414596-92483953 (-)
FVB/NJ MGP_FVBNJ_G0033743
 protein coding gene Chr8:91361261-91432218 (-)
LP/J MGP_LPJ_G0033888
 protein coding gene Chr8:96846855-96916627 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033785
 protein coding gene Chr8:105789475-105860485 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034495
 protein coding gene Chr8:95623648-95703317 (-)
PWK/PhJ MGP_PWKPhJ_G0032700
 protein coding gene Chr8:91773114-91845435 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032537
 protein coding gene Chr8:94489622-94560433 (-)
WSB/EiJ MGP_WSBEiJ_G0033110
 protein coding gene Chr8:96159013-96229207 (-)



Homology
more
  • Human Ortholog
    CNGB1, cyclic nucleotide gated channel subunit beta 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNGB1, cyclic nucleotide gated channel subunit beta 1
  • Synonyms
    CNCG2, CNCG3L, CNCG4, CNG4, CNGB1B, GAR1, GARP, GARP2, RCNC2, RCNCb, RCNCbeta, RP45
  • Links
    NCBI Gene ID: 1258
    neXtProt AC: NX_Q14028
    UniProt: Q14028

  • Chr Location
    16q21; chr16:57882340-57971128 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cngb1 mouse models; 2 with human CNGB1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display postnatal lethality, reduced body size and weight, and retinal rod degeneration followed by cone degeneration. Mice homozygous for an allele lacking the calmodulin-binding domain exhibit defective olfactory neural signaling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    854
  • Tissues
    19
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031789 Ensembl Gene Model | MGI Sequence Detail 67541 C57BL/6J ±  kb
    transcript ENSMUST00000119870 Ensembl | MGI Sequence Detail 6189 Not Applicable  
    polypeptide ENSMUSP00000113827 Ensembl | MGI Sequence Detail 1325 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding domain superfamily
      IPR050866 Cyclic Nucleotide-Gated Cation Channel
      IPR014710 RmlC-like jelly roll fold
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2385303, MGI:3037817
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 7
      Phenotypes 35
    • Earliest
      J:86879 Bradley J, et al., Nomenclature for ion channel subunits. Science. 2001 Dec 7;294(5549):2095-6
    • Latest
      J:350750 Scalabrino ML, et al., Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa. Nat Commun. 2023 Dec 12;14(1):8256
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory