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Npas4 Gene Detail
Summary
  • Symbol
    Npas4
  • Name
    neuronal PAS domain protein 4
  • Synonyms
    LE-PAS, Npas4, Nxf
  • Feature Type
    protein coding gene
  • IDs
    MGI:2664186
    NCBI Gene: 225872
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5034383-5040344 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2664186
 protein coding gene Chr19:5034381-5053467 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024684
 protein coding gene Chr19:1905644-1911260 (-)
A/J MGP_AJ_G0024650
 protein coding gene Chr19:1803281-1808897 (-)
AKR/J MGP_AKRJ_G0024623
 protein coding gene Chr19:1856531-1862147 (-)
BALB/cJ MGP_BALBcJ_G0024650
 protein coding gene Chr19:1797749-1803365 (-)
C3H/HeJ MGP_C3HHeJ_G0024418
 protein coding gene Chr19:1857650-1863266 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025097
 protein coding gene Chr19:1961599-1967215 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022527
 protein coding gene Chr19:1732889-1738490 (-)
CAST/EiJ MGP_CASTEiJ_G0023890
 protein coding gene Chr19:1886176-1891792 (-)
CBA/J MGP_CBAJ_G0024389
 protein coding gene Chr19:2043964-2049580 (-)
DBA/2J MGP_DBA2J_G0024517
 protein coding gene Chr19:1792439-1798055 (-)
FVB/NJ MGP_FVBNJ_G0024484
 protein coding gene Chr19:1793435-1799051 (-)
LP/J MGP_LPJ_G0024603
 protein coding gene Chr19:1901435-1907051 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024514
 protein coding gene Chr19:1929161-1934777 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025145
 protein coding gene Chr19:1853151-1858767 (-)
PWK/PhJ MGP_PWKPhJ_G0023636
 protein coding gene Chr19:1828567-1834183 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023441
 protein coding gene Chr19:1843776-1849397 (-)
WSB/EiJ MGP_WSBEiJ_G0023952
 protein coding gene Chr19:1865064-1870680 (-)



Homology
more
  • Human Ortholog
    NPAS4, neuronal PAS domain protein 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPAS4, neuronal PAS domain protein 4
  • Synonyms
    bHLHe79, Le-PAS, NXF, PASD10
  • Links
    NCBI Gene ID: 266743
    neXtProt AC: NX_Q8IUM7
    UniProt: Q8IUM7

  • Chr Location
    11q13.2; chr11:66409158-66426707 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hyperactivity, seizures and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    114
  • cDNA Data
    15
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045903 Ensembl Gene Model | MGI Sequence Detail 5962 C57BL/6J ±  kb
transcript ENSMUST00000056129 Ensembl | MGI Sequence Detail 3622 Not Applicable  
polypeptide ENSMUSP00000062992 Ensembl | MGI Sequence Detail 802 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 15
    Primer pair 4
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 77
    Developmental Gene Expression 9
    Gene Ontology 15
    Phenotypes 35
  • Earliest
    J:80366 Ooe N, et al., Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. Mol Cell Biol. 2004 Jan;24(2):608-16
  • Latest
    J:354626 Kushinsky D, et al., Daily light-induced transcription in visual cortex neurons drives downward firing rate homeostasis and stabilizes sensory processing. Cell Rep. 2024 Sep 24;43(9):114701
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory