Tg(PSEN1*L286V)1274Citr
Transgene Detail

Summary

• Symbol: Tg(PSEN1*L286V)1274Citr
• Name: transgene insertion 1274, Martin Citron
• MGI ID: MGI:2664251
• Synonyms: Tg(PSEN1-L286V)3Citr
• Transgene: Tg(PSEN1*L286V)1274Citr Location: unknown
• Alliance: Tg(PSEN1*L286V)1274Citr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PSEN1*L286V)1274Citr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

  Transgene codes for a protein with a leucine to valine mutation.

• Mutation details: A human PSEN1 cDNA sequence with an engineered leucine to valine mutation at residue 286 (L286V) was used for the transgene. (J:83861)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:83861 Citron M, et al., Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med. 1997 Jan;3(1):67-72
• All: 6 reference(s)