Il22ra2 MGI Mouse Gene Detail - MGI:2665114 - interleukin 22 receptor, alpha 2

Symbol

Il22ra2
Name

interleukin 22 receptor, alpha 2
Synonyms

Il-22bp

Feature Type

protein coding gene
IDs

MGI:2665114
NCBI Gene: 237310
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:19497776-19510429 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 8.52 cM
Mapping Data

1 experiment

SNPs within 2kb

377 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2665114	protein coding gene	Chr10:19497746-19510429 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017046	protein coding gene	Chr10:17347063-17360664 (+)
A/J	MGP_AJ_G0017024	protein coding gene	Chr10:16691239-16704039 (+)
AKR/J	MGP_AKRJ_G0016988	protein coding gene	Chr10:16965967-16978648 (+)
BALB/cJ	MGP_BALBcJ_G0016982	protein coding gene	Chr10:16745981-16758620 (+)
C3H/HeJ	MGP_C3HHeJ_G0016807	protein coding gene	Chr10:17287109-17299760 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017444	protein coding gene	Chr10:17767901-17780584 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015149	protein coding gene	Chr10:15697266-15710129 (+)
CAST/EiJ	MGP_CASTEiJ_G0016389	protein coding gene	Chr10:17165655-17177964 (+)
CBA/J	MGP_CBAJ_G0016779	protein coding gene	Chr10:18584382-18597041 (+)
DBA/2J	MGP_DBA2J_G0016887	protein coding gene	Chr10:16570229-16582888 (+)
FVB/NJ	MGP_FVBNJ_G0016882	protein coding gene	Chr10:16327070-16339753 (+)
LP/J	MGP_LPJ_G0016962	protein coding gene	Chr10:17153036-17165691 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016912	protein coding gene	Chr10:18830882-18844621 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017482	protein coding gene	Chr10:16951901-16964584 (+)
PWK/PhJ	MGP_PWKPhJ_G0016174	protein coding gene	Chr10:16441492-16453884 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015957	protein coding gene	Chr10:17115364-17128214 (+)
WSB/EiJ	MGP_WSBEiJ_G0016451	protein coding gene	Chr10:17047188-17059849 (+)

Human Ortholog

IL22RA2, interleukin 22 receptor subunit alpha 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL22RA2, interleukin 22 receptor subunit alpha 2
Synonyms

CRF2-10, CRF2-S1, CRF2X, IL-22BP, IL-22RA2, IL-22R-alpha-2, ZCYTOR16
Links

HGNC:14901

NCBI Gene ID: 116379

neXtProt AC: NX_Q969J5

UniProt: Q969J5
Chr Location

6q23.3; chr6:137143820-137173648 (-) GRCh38

MGI Vertebrate Homology

Il22ra2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL22RA2
Gene Tree

Il22ra2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

8
Genomic Mutations

1 involving Il22ra2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display accelerated tumor formation in a colitis associated colon cancer model.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN il22ra2

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All Sequences

37
RefSeq

2
UniProt

5
CCDS

CCDS23717.1

Ensembl

ENSMUSG00000039760 (Evidence)
NCBI Gene

237310

			Length	Strain/Species	Flank
genomic	237310	NCBI Gene Model \| MGI Sequence Detail	12654	C57BL/6J	± kb
transcript	NM_178258	RefSeq \| MGI Sequence Detail	2468	C57BL/6
polypeptide	Q80XF5	UniProt \| EBI \| MGI Sequence Detail	230	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009000 interleukin-22 receptor subunit alpha-2

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR015373 Interferon/interleukin receptor domain

IPR050650 Type II Cytokine and Tissue Factor Receptors

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All nucleic 7

cDNA 7

Microarray probesets 2

Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 24
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:346205 Zhang Z, et al., IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung Injury. Am J Pathol. 2024 Mar;194(3):338-352

TSS for Il22ra2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92552	Chr10:19497740-19497752 (+)	-30 bp
Tssr92553	Chr10:19497762-19497783 (+)	-3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24