Tg(Myh6-tTA)6Smbf
Transgene Detail

Summary

• Symbol: Tg(Myh6-tTA)6Smbf
• Name: transgene insertion 6, Section of Myocardial Biology - Fishman Lab
• MGI ID: MGI:2665551
• Synonyms: 2.9alphatTA, alphaMHC-tTA, alphaMtTA, Tg(MHCAtTA)6Smbf
• Transgene: Tg(Myh6-tTA)6Smbf Location: unknown
• Alliance: Tg(Myh6-tTA)6Smbf page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The transgene consists of a rat Myh6 promoter and a tetracycline transactivator sequence. Transgene expression in cardiac tissue was confirmed by Northern blot analysis. 2.9 kb of rat Myh6 promoter sequences directs transgene expression in the heart starting at embryonic day E7.5. (J:82692)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available

Notes

Transgenic line 6 showed the strongest cardiac transgene expression and was used for analysis.

References

• Original: J:82692 Yu Z, et al., Conditional transgene expression in the heart. Circ Res. 1996 Oct;79(4):691-7
• All: 83 reference(s)