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Ifne Gene Detail
Summary
  • Symbol
    Ifne
  • Name
    interferon epsilon
  • Synonyms
    Ifne1, Ifnt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2667156
    NCBI Gene: 230405
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:88797775-88798438 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 42.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2667156
 protein coding gene Chr4:88797775-88798438 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028439
 protein coding gene Chr4:88785522-88786185 (-)
A/J MGP_AJ_G0028401
 protein coding gene Chr4:85685931-85686594 (-)
AKR/J MGP_AKRJ_G0028349
 protein coding gene Chr4:87803025-87803688 (-)
BALB/cJ MGP_BALBcJ_G0028420
 protein coding gene Chr4:85911924-85912587 (-)
C3H/HeJ MGP_C3HHeJ_G0028132
 protein coding gene Chr4:88528691-88529354 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028859
 protein coding gene Chr4:92174114-92174777 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026154
 protein coding gene Chr4:81634852-81635515 (-)
CAST/EiJ MGP_CASTEiJ_G0027573
 protein coding gene Chr4:86370003-86370666 (-)
CBA/J MGP_CBAJ_G0028102
 protein coding gene Chr4:95017246-95017909 (-)
DBA/2J MGP_DBA2J_G0028252
 protein coding gene Chr4:85445342-85446005 (-)
FVB/NJ MGP_FVBNJ_G0028219
 protein coding gene Chr4:84384130-84384793 (-)
LP/J MGP_LPJ_G0028352
 protein coding gene Chr4:89079664-89080327 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028248
 protein coding gene Chr4:100003808-100004471 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028897
 protein coding gene Chr4:87946617-87947280 (-)
PWK/PhJ MGP_PWKPhJ_G0027297
 protein coding gene Chr4:83733321-83733984 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027118
 protein coding gene Chr4:85464317-85464980 (-)
WSB/EiJ MGP_WSBEiJ_G0027651
 protein coding gene Chr4:88151744-88152407 (-)



Homology
more
  • Human Ortholog
    IFNE, interferon epsilon
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNE, interferon epsilon
  • Synonyms
    IFN-E, IFNE1, IFNT1, INFE1, PRO655
  • Links
    NCBI Gene ID: 338376
    neXtProt AC: NX_Q86WN2
    UniProt: Q86WN2

  • Chr Location
    9p21.3; chr9:21480839-21482313 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to HSV-2 and Chlamydia infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    2
  • cDNA Data
    4
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 230405 NCBI Gene Model | MGI Sequence Detail 664 C57BL/6J ±  kb
transcript NM_177348 RefSeq | MGI Sequence Detail 664 ZRU/MplStud  
polypeptide Q80ZF2 UniProt | EBI | MGI Sequence Detail 192 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:91582 Hardy MP, et al., Characterization of the type I interferon locus and identification of novel genes. Genomics. 2004 Aug;84(2):331-45
  • Latest
    J:340495 Marks ZRC, et al., Interferon-epsilon is a tumour suppressor and restricts ovarian cancer. Nature. 2023 Aug;620(7976):1063-1070
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory