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Irgq Gene Detail
Summary
  • Symbol
    Irgq
  • Name
    immunity-related GTPase family, Q
  • Synonyms
    FKSG27
  • Feature Type
    protein coding gene
  • IDs
    MGI:2667176
    NCBI Gene: 210146
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24230114-24238025 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 11.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    295 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2667176
 protein coding gene Chr7:24230073-24238025 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031832
 protein coding gene Chr7:22858837-22866744 (+)
A/J MGP_AJ_G0031811
 protein coding gene Chr7:22333945-22341793 (+)
AKR/J MGP_AKRJ_G0031740
 protein coding gene Chr7:22835378-22843225 (+)
BALB/cJ MGP_BALBcJ_G0031817
 protein coding gene Chr7:22553731-22561649 (+)
C3H/HeJ MGP_C3HHeJ_G0031537
 protein coding gene Chr7:23254643-23262547 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032280
 protein coding gene Chr7:23613258-23621174 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029338
 protein coding gene Chr7:23803152-23811298 (+)
CAST/EiJ MGP_CASTEiJ_G0030878
 protein coding gene Chr7:16729850-16737723 (+)
CBA/J MGP_CBAJ_G0031502
 protein coding gene Chr7:24501770-24509700 (+)
DBA/2J MGP_DBA2J_G0031656
 protein coding gene Chr7:22247775-22255710 (+)
FVB/NJ MGP_FVBNJ_G0031609
 protein coding gene Chr7:22218572-22226490 (+)
LP/J MGP_LPJ_G0031735
 protein coding gene Chr7:23219609-23227604 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031646
 protein coding gene Chr7:24265571-24273446 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032312
 protein coding gene Chr7:22558020-22565931 (+)
PWK/PhJ MGP_PWKPhJ_G0030602
 protein coding gene Chr7:17139740-17147762 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030432
 protein coding gene Chr7:13886124-13893940 (+)
WSB/EiJ MGP_WSBEiJ_G0030981
 protein coding gene Chr7:22678997-22686908 (+)



Homology
more
  • Human Ortholog
    IRGQ, immunity related GTPase Q
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRGQ, immunity related GTPase Q
  • Synonyms
    FKSG27, IRGQ1
  • Links
    NCBI Gene ID: 126298
    neXtProt AC: NX_Q8WZA9
    UniProt: Q8WZA9

  • Chr Location
    19q13.31; chr19:43584367-43596134 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    104
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041037 Ensembl Gene Model | MGI Sequence Detail 7912 C57BL/6J ±  kb
    transcript ENSMUST00000049020 Ensembl | MGI Sequence Detail 6083 Not Applicable  
    polypeptide ENSMUSP00000036699 Ensembl | MGI Sequence Detail 583 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 104
      cDNA 104

      Microarray probesets 6
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 8
    • Earliest
      J:150323 Miyairi I, et al., The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection. J Immunol. 2007 Aug 1;179(3):1814-24
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory